Novel Antimicrobials for Eye Infections

治疗眼部感染的新型抗菌药物 摘要 细菌性眼部感染经常作为矫正手术或接触透镜使用的并发症而出现。越来越 许多此类事件对现有抗生素没有反应，导致不可逆转的眼睛和视力损伤 损失新的抗菌化合物的鉴定是迫切需要的。该项目致力于发展 针对一个新的目标，细菌凝聚素的抗菌剂。凝聚素在全球 染色体的组织和有助于在不同的生物体中的遗传信息的忠实分离。在 铜绿假单胞菌，凝聚素调节嗜酸性和固着表型之间的转换， 在眼部感染过程中的毒力所需的。该项目旨在验证凝聚素作为一个合理的药物靶点 并开发小分子冷凝抑制剂。主要关注铜绿假单胞菌。但 抑制剂也显示出抗其它病原体的活性。

Novel Antimicrobials for Eye Infections ABSTRACT Bacterial eye infections frequently arise as a complication of corrective surgery or contact lens use. A growing number of such incidents fail to respond to available antibiotics resulting in irreversible eye damage and vision loss. Identification of new antibacterial compounds is urgently needed. This project pursues the development of antimicrobials against a novel target, bacterial condensins. Condensins play a central role in global chromosome organization and contribute to faithful segregation of genetic information in diverse organisms. In Pseudomonas aeruginosa, condensins regulate switching between planktonic and sessile phenotypes and are required for virulence during eye infection. This project seeks to validate condensins as a plausible drug target and develop small molecule condensin inhibitors. The primary focus will be on P. aeruginosa. However, the inhibitors display activity against other pathogens as well.