Systems Approach to Understanding Cardiac Arrhythmias Mechanisms

摘要 心脏病是美国和发达国家的头号死因，但却是有效的药物 治疗方法仍然缺乏。为了开发更好、更有效的治疗心脏的方法 疾病，对于医生和科学家来说，获得准确和深入的信息至关重要 了解心脏疾病的细胞和分子机制。近几十年来， 该领域的研究人员已经积累了越来越多的实验数据 分子、细胞、组织和器官水平。然而，重要的概念进展 在心脏领域需要整合来自多个尺度的知识。在这里，我们拿着 向前迈出必要的一步，将实验数据整合到量化模型中，从而能够使用 了解细胞复杂相互作用的数学工具和计算能力 和心脏中的分子。这一系列会议的独特设计是将 通过实验研究和数学建模，实现了对非均匀分布的深入理解 控制心脏功能和心脏病的线性动力系统。 这次会议是我们的跨学科研讨会系列中的第六次，主题是 了解心脏兴奋-收缩耦合的方法“。前5次会议 从科学界收到了压倒性的积极评价，并导致 大量影响很大的出版物。这次拟议的会议将继续独一无二的 将心脏领域的实验研究和模型研究相结合的跨学科形式 心律不齐。主题将集中在心脏兴奋、钙离子的前沿研究上。 信号、收缩力学和机械转导，重点是整合 动态系统，以获得对心脏病的全面和全面的了解。 本次会议的目标将集中在(1)总结当前在 重点领域，(2)确定需要进行更多调查的共识和争议，(3) 在实验者和模型师之间交换想法、数据和信息，以促进 跨学科协作。会议成果将以白字形式汇总 在心脏病领域有广泛影响的领先科学期刊上发表的论文。

ABSTRACT Heart diseases are the No.1 cause of death in the US and developed world, but effective drug therapies are still lacking. In order to develop better and more effective therapies to treat heart diseases, it is critically important for physicians and scientists to gain accurate and in-depth understanding of the cellular and molecular mechanisms of heart diseases. In recent decades, researchers in the field have been accumulating more and more experimental data from molecular, to cellular, and to tissue and organ levels. However, important conceptual advances in the cardiac field require integration of the knowledge from multiple scales. Here we take the necessary step forward to integrate experimental data into quantitative models that enable using mathematical tools and computational power to understand the complex interactions of the cells and molecules in the heart. The unique design of this conference series is to combine experimental study and mathematical modeling to achieve in-depth understanding of the non- linear dynamic systems that control cardiac function and heart diseases. This conference is the 6th in our interdisciplinary symposium series entitled “System’s Approach to Understand Cardiac Excitation-Contraction Coupling”. The previous 5 conferences have received overwhelmingly positive evaluations from scientific community and resulted in numerous high impact publications. This proposed conference will continue the uniquely interdisciplinary format to combine experimental and modeling studies in the field of cardiac arrhythmias. The topics will be focused on the cutting-edge research in cardiac excitation, Ca2+ signaling, contraction mechanics and mechanotransduction, with emphases on integrating the the dynamic systems to gain a holistic and comprehensive understanding of heart diseases. The goal of this conference will be focused on (1) summarizing current state of research in the focus area, (2) identifying consensus and controversy that warrant more investigation, (3) exchanging ideas, data, and information among the experimentalists and modelers to facilitate interdisciplinary collaborations. The conference results will be summarized in the form of white papers to be published in leading scientific journals that have broad impact in heart disease field.