Systems Approach to Understanding Cardiovascular Disease and Arrhythmias - Cell diversity in the cardiovascular system, cell-autonomous and cell-cell signaling

了解心血管疾病和心律失常的系统方法 - 心血管系统中的细胞多样性、细胞自主和细胞间信号传导

• 批准号: 10386681
• 负责人: Donald M Bers
• 金额: $ 3万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-11-23 至 2022-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10386681
• 关键词: Area; Arrhythmia; Biophysics; Black race; Blood Vessels; Cardiac; Cardiac Myocytes; Cardiovascular Diseases; Cardiovascular Physiology; Cardiovascular system; Cause of Death; Cell Communication; Cells; Collaborations; Communication; Communities; Complex; Computer Models; Consensus; Coupling; Data; Databases; Development; Disabled Persons; Disease; Disease Progression; Endothelial Cells; Endothelium; Evaluation; Event; Experimental Models; Feedback; Fibroblasts; Formulation; Functional disorder; Goals; Grant; Heart; Heart Diseases; Heart failure; Hypertension; Immune; Individual; Interdisciplinary Study; International; Investigation; Journals; Knowledge; Latin America; Link; Mathematics; Minority; Minority Groups; Minority Participation; Minority Women; Mission; Modeling; Molecular; Muscle Cells; National Heart, Lung, and Blood Institute; Nature; Neurons; Nonlinear Dynamics; Oral; Organ; Outcome; Paper; Participant; Persons; Physicians; Physiology; Play; Property; Publications; Publishing; Research; Research Personnel; Role; Scientist; Series; Signal Transduction; Smooth Muscle Myocytes; Societies; Stroke; Study models; System; Therapeutic; Time; Tissues; United States; Vascular Diseases; Vascular Smooth Muscle; Vasospasm; Woman; Work; career; career networking; cell type; complex biological systems; design; dynamic system; effective therapy; experimental study; innovation; intercellular communication; interdisciplinary collaboration; mathematical model; meetings; novel therapeutic intervention; programs; social media; success; symposium; tool; web site

UC Davis Cardiovascular Symposium Systems Approach to Understanding Cardiovascular Disease and Arrhythmias -Cell diversity in the cardiovascular system, cell-autonomous and cell-cell signaling- Cardiovascular diseases, including hypertension, heart failure, arrhythmias and stroke, are the number one killer in the developed world. In order to develop better and more effective therapies to treat heart diseases, it is critically important for scientists and physicians to obtain in-depth and accurate understanding of the mechanisms underlying heart and vascular function and dysfunction. In recent decades, researchers studying heart and vascular diseases have been accumulating more and more experimental data from molecular, to cellular, and to tissue and organ levels. However, there is a critical need to integrate these data into mechanistic and quantitative models to understand emergent properties of complex biological system such as arrhythmias and vasospasms that are often counterintuitive (due to non-linear dynamics interactions). Moreover, it is important to understand how different cells of the cardiovascular system may interact with each other in physiology and disease. Here we propose to take the necessary step forward to integrate experimental data into quantitative models that enable using mathematical tools and computational power to understand the complex interactions of the cells and molecules in the cardiovascular system. The unique design of this conference series is to combine experimental study and mathematical modeling to achieve in-depth understanding of the dynamic systems that control cardiovascular function and diseases. The proposed interdisciplinary conference is the 7th in this series. This new installment of the conference will integrate, for the first time, studies in cardiac and vascular tissue. The previous conferences have received overwhelmingly positive evaluations from attendees and resulted in high impact publications. The proposed conference will combine experimental and modeling studies in the field of cardiac and vascular physiology, with topics focused on cell diversity in the cardiovascular system, as it is becoming increasingly evident that a complex interplay of abnormal signaling events among various cell types, including myocytes, fibroblasts, endothelial, neuronal, immune cells, etc. plays a central role in cardiovascular disease. The emphasis of this conference will be on (1) summarizing current state of research in the focus area, (2) identifying consensus and controversy that warrant more investigation, and (3) exchanging ideas, data, and information among the experimentalists and modelers to facilitate interdisciplinary collaborations. The conference results will be summarized in the form of comprehensive review papers, which will be published in leading scientific journals that have broad impact on the research community, as before.

加州大学戴维斯分校心血管研讨会 了解心血管疾病和心律失常的系统方法 - 心血管系统中的细胞多样性，细胞自主和细胞间信号传导- 包括高血压、心力衰竭、心律失常和中风在内的心血管疾病是头号杀手 in the developed发达world世界.为了开发更好更有效的治疗心脏病的方法， 对科学家和医生来说，深入和准确地了解 心脏和血管功能和功能障碍的潜在机制。近几十年来，研究人员 心脏和血管疾病已经积累了越来越多的实验数据，从分子， 细胞水平，以及组织和器官水平。然而，迫切需要将这些数据集成到机械化的 和定量模型，以了解复杂生物系统的涌现特性，如心律失常 以及通常违反直觉的血管痉挛（由于非线性动力学相互作用）。而且是 重要的是要了解心血管系统的不同细胞如何相互作用， 生理学和疾病。在这里，我们建议采取必要的步骤，将实验数据整合到 定量模型，使使用数学工具和计算能力，以了解复杂的 心血管系统中细胞和分子的相互作用。本次会议系列的独特设计 是将联合收割机的实验研究和数学建模相结合， 控制心血管功能和疾病的系统。本次跨学科会议是第七届 在这个系列中。会议的这一新的分期付款将首次整合心脏和心脏病的研究， 血管组织前几届会议得到了与会者压倒性的积极评价 并出版了影响深远的出版物。拟议的会议将结合联合收割机实验和建模 心脏和血管生理学领域的研究，主题集中在心血管系统中的细胞多样性 系统，因为越来越明显，异常信号事件之间的复杂相互作用 各种类型的细胞，包括肌细胞、成纤维细胞、内皮细胞、神经细胞、免疫细胞等，都起着核心作用 在心血管疾病中。本次会议的重点将是（1）总结研究现状 在重点领域，（2）确定需要更多调查的共识和争议，（3）交换 想法，数据和信息之间的实验和建模，以促进跨学科的合作。 会议成果将以综合评论论文的形式进行总结，并予以发表 在领先的科学期刊，有广泛的影响力的研究界，像以前一样。