Systems Approach to Understanding Cardiovascular Disease and Arrhythmias - Cell diversity in the cardiovascular system, cell-autonomous and cell-cell signaling

加州大学戴维斯分校心血管研讨会 认识心血管疾病和心律失常的系统方法 -心血管系统中的细胞多样性，细胞自主和细胞间信号- 心血管疾病，包括高血压、心力衰竭、心律失常和中风，是头号杀手。 在发达国家。为了开发更好、更有效的治疗心脏病的方法， 对于科学家和医生来说，深入和准确地了解 心脏和血管功能及功能障碍的潜在机制。近几十年来，研究人员研究 心脏和血管疾病已经积累了越来越多的实验数据，从分子到 细胞，以及组织和器官水平。然而，迫切需要将这些数据整合到机械化中 以及用于理解复杂生物系统(如心律失常)紧急特性的定量模型 血管痉挛通常是违反直觉的(由于非线性动力学相互作用)。此外，它是 重要的是要了解心血管系统的不同细胞如何在 生理学和疾病。在这里，我们建议采取必要的步骤，将实验数据整合到 能够使用数学工具和计算能力来理解复杂情况的定量模型 心血管系统中细胞和分子的相互作用。这一系列会议的独特设计 是将实验研究和数学建模相结合，实现对动态的深入理解 控制心血管功能和疾病的系统。拟召开的跨学科会议是7日。 在这个系列中。新一期会议将首次整合心脏和心脏方面的研究。 血管组织。以往的会议都收到了与会者的绝大多数积极评价 并产生了影响很大的出版物。拟议的会议将结合实验和建模 心脏和血管生理学领域的研究，主题集中在心血管细胞多样性 系统，因为越来越明显的是，异常信号事件之间的复杂相互作用 各种类型的细胞，包括肌细胞、成纤维细胞、内皮细胞、神经元细胞、免疫细胞等发挥着核心作用。 在心血管疾病方面。这次会议的重点将是(1)总结当前的研究状况 在重点领域，(2)确定需要更多调查的共识和争议，以及(3)交流 实验人员和建模人员之间的想法、数据和信息，以促进跨学科协作。 会议成果将以综合综述论文的形式进行总结，并将发表 一如既往地在对研究界产生广泛影响的领先科学期刊上发表文章。

UC Davis Cardiovascular Symposium Systems Approach to Understanding Cardiovascular Disease and Arrhythmias -Cell diversity in the cardiovascular system, cell-autonomous and cell-cell signaling- Cardiovascular diseases, including hypertension, heart failure, arrhythmias and stroke, are the number one killer in the developed world. In order to develop better and more effective therapies to treat heart diseases, it is critically important for scientists and physicians to obtain in-depth and accurate understanding of the mechanisms underlying heart and vascular function and dysfunction. In recent decades, researchers studying heart and vascular diseases have been accumulating more and more experimental data from molecular, to cellular, and to tissue and organ levels. However, there is a critical need to integrate these data into mechanistic and quantitative models to understand emergent properties of complex biological system such as arrhythmias and vasospasms that are often counterintuitive (due to non-linear dynamics interactions). Moreover, it is important to understand how different cells of the cardiovascular system may interact with each other in physiology and disease. Here we propose to take the necessary step forward to integrate experimental data into quantitative models that enable using mathematical tools and computational power to understand the complex interactions of the cells and molecules in the cardiovascular system. The unique design of this conference series is to combine experimental study and mathematical modeling to achieve in-depth understanding of the dynamic systems that control cardiovascular function and diseases. The proposed interdisciplinary conference is the 7th in this series. This new installment of the conference will integrate, for the first time, studies in cardiac and vascular tissue. The previous conferences have received overwhelmingly positive evaluations from attendees and resulted in high impact publications. The proposed conference will combine experimental and modeling studies in the field of cardiac and vascular physiology, with topics focused on cell diversity in the cardiovascular system, as it is becoming increasingly evident that a complex interplay of abnormal signaling events among various cell types, including myocytes, fibroblasts, endothelial, neuronal, immune cells, etc. plays a central role in cardiovascular disease. The emphasis of this conference will be on (1) summarizing current state of research in the focus area, (2) identifying consensus and controversy that warrant more investigation, and (3) exchanging ideas, data, and information among the experimentalists and modelers to facilitate interdisciplinary collaborations. The conference results will be summarized in the form of comprehensive review papers, which will be published in leading scientific journals that have broad impact on the research community, as before.