Initial Development and Validation of a Translational Approach to AUD Definition and Measurement

(7)项目总结/摘要 具体目标 目前的提议旨在整合AUD的核心结构和理论，包括有希望的内表型。 到RDoC框架中。该系统集成将用于导出一组构造有效AUD “诊断标准”将在大学、社区和治疗样本中得到验证。由此产生的衡量标准 将由基于表型的标准组成，这些标准非常适合治疗目的，因为它们直接与 个体化的治疗目标，符合精准医学的做法。 方法 为了达到这些目标，本文系统地回顾了AUD的病因学、核心理论和重要的 将进行内表型分析。开创性的、可复制的调查结果将纳入RDoC汇总表(目标1)。 一旦确定了核心AUD域，将进行第二次审查，目标是确定 现有的问卷和访谈项目，涉及每个与成瘾相关的RDoC领域。这个 谢尔博士和顾问将评估这些项目/领域分类的适当性，以便 就分类的有效性提供反馈(目标2)。最后，将使用目标2中确定的项目 利用先进的统计方法，如IRT，在Dr。 Merkle和Bucholz(顾问)和Sher博士(赞助商；目标3)。MTurk参与者样本(N=1,000) 将用于项目评估阶段的测量开发，并对一名大学生(N=1,000)进行门诊 (n=150)，治疗(N=150)样本将用于临床改进和外部验证阶段。 长期目标 拟议项目的总体目标是制定一种客观的澳元汇率衡量标准，通过以下方式提供信息 基础翻译科学，与RDoC框架一致。通过系统地整合种子 将AUD病因学纳入RDoC框架的工作，这是本研究之前尚未完成的工作 处于有利地位，可以产生一种结构有效的AUD测量方法，可用于指导临床治疗 决定。建议的项目有助于开发个性化的澳元。 通过关注个人出现症状和症状的特定领域进行干预 因此，克服了目前与治疗广泛异质性AUD相关的问题。 培训目标 目前的建议将成为我建设更多 用于评估和治疗AUDS的可靠和构建有效的诊断框架。这个 计划将允许申请者在翻译科学及其应用方面获得宝贵的经验 RDoC框架，以及大数据分析、测试构建和心理测评方面的知识。这个 这些培训体验的性质将通过密切协作为我提供身临其境的体验 有导师，接触到新的研究和统计方法。因此，成功地完成了这些 培训目标将为我获得终身教职研究职位的职业目标奠定基础 调查AUD病因学和评估，目的是利用这些发现来改善临床结果。

(7) PROJECT SUMMARY/ABSTRACT Specific Aims The current proposal aims to integrate core AUD constructs and theories, including promising endophenotypes, into an RDoC framework. This systematic integration will be used to derive a set of construct valid AUD “diagnostic criteria” that will be validated in a college, community, and treatment sample. The resulting measure will consist of phenotypic-based criteria that are well-suited for treatment purposes, given they match directly to individual treatment targets, consistent with the precision medicine approach. Method Towards these aims, a systematic review of reviews on the topics of AUD etiology, core theories, and important endophenotypes will be conducted. Seminal, replicable findings will be integrated into the RDoC matrix (Aim 1). Once the core AUD domains have been identified, a second review will be conducted with the goal of identifying existing questionnaire and interview items that address each addiction-related RDoC domain. The appropriateness of these item/domain categorizations will be evaluated by Dr. Sher and consultants in order to provide feedback on the validity of the categorizations (Aim 2). Lastly, the items identified in Aim 2 will be used to develop a diagnostic measure of AUD using advanced statistical methods such as IRT, using the help of Drs. Merkle and Bucholz (consultants) and Dr. Sher (sponsor; Aim 3). An MTurk sample of participants (N = 1,000) will be used for the item evaluation stage of measure development, and a college student (N = 1,000), outpatient (N = 150), and treatment (N = 150) sample will be used for the clinical refinement and external validation stage. Long-Term Objectives The over-arching goal of the proposed project is to develop an objective measure of AUD that is informed by basic translational science, consistent with the RDoC framework. Through the systematic integration of seminal work on AUD etiology into an RDoC framework, which has not been previously accomplished, the current study is well-positioned to produce a construct-valid measure of AUD that can be used to inform clinical treatment decisions. The proposed project can contribute to the movement towards developing personalized AUD intervention efforts by focusing on the specific domains in which individuals are experiencing symptoms and therefore overcoming the current issues related to treatment of widely heterogeneous AUD presentation. Training Aims The current proposal will serve as an important starting place for my long-term objective of building a more reliable and construct-valid diagnostic framework for use in the assessment and treatment of AUDs. The proposal will allow the applicant to gain valuable experience in translational science and its application within an RDoC framework, plus knowledge in analysis of big data, test construction, and psychometric evaluation. The nature of these training experiences will provide me with an immersive experience through close collaboration with mentors and exposure to new research and statistical methods. Thus, successful completion of these training aims will provide the foundation for my career objective of obtaining a tenure-track research position investigating AUD nosology and assessment with the goal of using these findings to improve clinical outcomes.