Biostatistics and Bioinformatics Core

生物统计学和生物信息学核心摘要/摘要 子宫内膜癌孢子计划的生物统计和生物信息学核心将支持 项目，并协助其他核心设计和解释临床和临床前实验， 以及数据的获取和管理。核心服务将是项目临床试验的关键， 以及他们对高维基因表达谱(GEP)方法的使用，下一代 测序(NGS)和反相蛋白质阵列(RPPA)。核心将结合声音实验 每个项目中的设计原则，具体到正在解决的科学问题。每个项目都将是 提供量身定制的分析，并附有适当的、有时是新颖的生物统计学或 生物信息学方法。核心领导将与项目调查人员合作，确定以下量化措施 可用于测试研究假设，包括确定样本大小以确保有足够的力量 学习。核心领导将定期与项目调查人员磋商，讨论设计和 开展研究项目，评估分析结果，讨论潜在的新研究计划，以及 孢子内的指示，并促进研究结果的发表。核心和项目之间的互动， 以及其他整合，将通过一个网上可访问的相关信息数据库提供便利 由每个项目，由核心开发和维护。 生物统计和生物信息学核心的主要目标是： 1.在实验室实验的设计和实施方面提供生物统计学和生物信息学专业知识 由本申请中提议的研究产生的临床试验。 2.对孢子下收集的所有数据提供生物统计和生物信息学分析和解释 项目、职业提升计划项目、发展项目和其他核心项目。 3.协作并协助所有项目调查人员发表科学成果。 4.开发和维护一个可上网访问的、专门针对孢子的所有项目相关信息数据库。

Biostatistics and Bioinformatics Core SUMMARY/ABSTRACT The Biostatistics and Bioinformatics Core for the Endometrial Cancer SPORE program will support the Projects, and assist the other Cores, in the design and interpretation of clinical and preclinical experiments, and the acquisition and management of data. Core services will be critical for the clinical trials of the Projects, and their use of high-dimensional methodologies of gene expression profiling (GEP), next-generation sequencing (NGS) and Reverse Phase Protein Arrays (RPPAs). The Core will incorporate sound experimental design principles within each Project, specific to the scientific issues being addressed. Each Project will be provided with tailored analyses, accompanied by appropriate and sometimes novel biostatistical or bioinformatics methods. Core leaders will work with Project investigators to identify quantitative measures that can be used to test study hypotheses, including determining sample sizes to ensure sufficient power for the studies. The leaders of the Core will confer regularly with Project investigators to discuss the design and conduct of research projects, evaluate results of analyses, discuss potential new research initiatives and directions within the SPORE, and promote publication of findings. Interactions between the Core and Projects, as well as other integration, will be facilitated by a web-accessible database of relevant information generated by each Project, to be developed and maintained by the Core. The main objectives of the Biostatistics and Bioinformatics Core are to: 1. Provide biostatistics and bioinformatics expertise in the design and conduct of laboratory experiments and clinical trials arising from the research proposed in this application. 2. Provide biostatistics and bioinformatics analysis and interpretation of all data collected under the SPORE Projects, Career Enhancement Program Projects, Developmental Projects, and other Cores. 3. Collaborate and assist all project investigators with the publication of scientific results. 4. Develop and maintain a web-accessible, SPORE-specific database of relevant information for all Projects.