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Core 2: Biostatistics and Bioinformatics Core

核心2：生物统计学和生物信息学核心

基本信息

批准号：
10415967
负责人：
Ying Yuan
金额：
$ 20.26万
依托单位：
UNIVERSITY OF TX MD ANDERSON CAN CTR
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-08-20 至 2024-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10415967
关键词：
Address Basic Science Bioinformatics Biometry Cancer Center Clinical Research Clinical Sciences Clinical Trials Design Colorectal Cancer Conduct Clinical Trials Data Data Analyses Data Analytics Data Set Development Ensure Epigenetic Process Funding Genomics Goals Grant Lateral Logistics Malignant Neoplasms Malignant neoplasm of gastrointestinal tract Malignant neoplasm of pancreas Methodology Methods Morbidity - disease rate Organ Paper Proteomics Publications Publishing Reporting Reproducibility Reproducibility of Results Research Research Design Research Personnel Resources Site Statistical Data Interpretation Techniques Translational Research University of Texas M D Anderson Cancer Center Work analytical tool archive data archived data base career computerized data processing data acquisition data handling data management design experience experimental study innovation member models and simulation mortality preclinical study professor programs statistical service success

项目摘要

CORE 2 BIOSTATISTICS AND BIOINFORMATICS: Summary The Biostatistics and Bioinformatics Core for the MD Anderson GI SPORE will serve multiple needs for the planning and conduct of the SPORE's translational research goals. Based on a strong track record for providing biostatistics and bioinformatics support for translational research (including currently funded SPORE grants in other organ sites and NCI P01 grants), the Core will be a comprehensive, multi-lateral resource for designing clinical trials and basic science experiments, performing statistical analyses, developing innovative statistical methodology, and publishing the research results generated from this GI SPORE. The Core will be led by Dr. Jeffrey Morris, professor and deputy chair in the Department of Biostatistics at MDACC, with an exemplary cadre of co-investigators with varied expertise in all aspects of biostatistics and bioinformatics. The Specific Aims of the Biostatistics and Bioinformatics Core are: Specific Aim 1: To provide guidance in the design and conduct of clinical trials and other experiments, including genomics, arising from the ongoing research of the GI SPORE, including SPORE projects, developmental projects, and other cores. Specific Aim 2: To provide biostatistical and bioinformatic modeling, simulation techniques and data analyses needed by the Projects and other Cores to achieve their Specific Aims. Specific Aim 3: To generate statistical reports for all projects and assist project investigators to publish scientific results. Specific Aim 4: To develop and adapt innovative statistical and bioinformatics methods pertinent to translational cancer studies.

核心2生物统计学和生物信息学：总结 MD安德森GI孢子的生物统计学和生物信息学核心将满足规划和实施SPORE的转化研究目标。基于在以下方面的良好业绩记录，为转化研究提供生物统计学和生物信息学支持（包括目前资助的SPORE 其他器官中心的赠款和NCI P01赠款），核心将是一个全面的，多边的资源，设计临床试验和基础科学实验，进行统计分析，开发创新统计方法，并发表从这个GI孢子产生的研究结果。芯会由MDACC生物统计学系教授兼副主任Jeffrey Morris博士领导，在生物统计学和生物信息学的各个方面具有各种专门知识的模范共同研究者骨干。生物统计学和生物信息学核心的具体目标是：具体目标1：为临床试验和其他实验的设计和实施提供指导，包括基因组学，产生于正在进行的研究的GI孢子，包括孢子项目，发展项目和其他核心。具体目标2：提供生物统计学和生物信息学建模、模拟技术和数据分析项目和其他核心为实现其特定目标所需的资源。具体目标3：为所有项目生成统计报告，并协助项目调查人员发布科学成果。具体目标4：开发和调整与以下方面有关的创新统计和生物信息学方法：转化性癌症研究。