Behavioral Phenoptying Core

项目总结/摘要 行为表型核心（BPC） NIH BACPAC计划旨在“产生关于表型，内型， 机制、诊断、试验结果和治疗反应。. .慢性腰痛（CLBP） 这项提议，领导一个机械研究中心（MRC）作为更广泛的BACPAC倡议的一部分， 包括一个研究核心，利用密歇根大学的多学科团队， 20多年来一直在表征和研究各种各样的慢性疼痛状况。议员 核心团队领导或参与了大型临床和基于网络的项目的设计和实施， 需要临床和行为表型分析，如国防部（DoD）对海湾地区的研究， 战争疾病，NIH/NIDDK MAPP倡议，NIAMS CORT和行业注册试验。该公司- 该核心的主任和成员也参与了PROMIS的开发和验证 慢性重叠疾病的衍生指标，包括cLBP。对于此应用程序，行为 表型核心（BPC）教师设计了一个全面的表型电池，包括多个， 领域自我报告问卷（主要来自PROMIS，NINDS通用数据元素，或 美国国立卫生研究院慢性腰痛工作组的建议）沿着多模式评估 诸如流动监测的策略（例如，活动记录和生态瞬时评估（EMA））， 功能能力检查（具体目标2）。我们的表型发生在基线和纵向 并与神经生物学表型核心（NPC）的努力相一致 （具体目标3）。BPC团队还为研究项目的设计和选择做出了贡献。 研究的相关主要和次要结局，包括基于先验机制假设的 每项干预措施的预期行动的具体成果。为了支持研究的完整性 项目，该核心还设计了治疗保真度，依从性，可信度和预期的指数（例如， 具体目标1）。最后，BPC渴望通过我们的良好- cLBP患者的特征队列作为更大的NIH BACPAC倡议的资源， 为BACPAC贡献科学专业知识，研究方法和领导力。

PROJECT SUMMARY / ABSTRACT BEHAVIORAL PHENOTYPING CORE (BPC) The NIH BACPAC initiative is designed to “generate new knowledge regarding phenotypes, endotypes, mechanisms, diagnostics, trial outcomes, and therapeutic responsiveness . . . in chronic low back pain (cLBP). This proposal, to lead a Mechanistic Research Center (MRC) as part of the broader BACPAC initiative, includes a Research Core that takes advantage of a multidisciplinary team at University of Michigan which has been characterizing and studying a wide variety of chronic pain conditions for over 20 years. Members of this Core have either led or participated in the design and conduct of large clinical and network based projects that have required clinical and behavioral phenotyping such as the Department of Defense (DoD) studies of Gulf- War Illnesses, the NIH/NIDDK MAPP initiative, the NIAMS CORT, and registration trials for industry. The co- Directors and members of this Core have also been involved in the development and validation of PROMIS derived measures for chronic overlapping conditions which includes cLBP. For this application, the Behavioral Phenotyping Core (BPC) faculty have designed a comprehensive phenotyping battery that incorporates multi- domain self-report questionnaires (derived largely from PROMIS, the NINDS common data elements, or recommendations from the NIH Chronic Low Back Pain Task Force) along with multi-modal assessment strategies such as ambulatory monitoring (e.g., actigraphy and ecological momentary assessment (EMA)) and functional capacity examination (Specific Aim 2). Our phenotyping occurs at baseline and longitudinally throughout the project and corresponds with the effort of the Neurobiological Phenotyping Core (NPC) (Specific Aim 3). The BPC team has also contributed to the design of the research project and selection of relevant primary and secondary outcomes for the study including a priori mechanistic hypothesis-based outcomes specific to the purported actions of each intervention. In order to support the integrity of the research project, this Core also designed indices of treatment fidelity, adherence, credibility, and expectancy (e.g., Specific Aim 1). Finally, the BPC is eager to contribute to the broader BACPAC initiative by having our well- characterized cohort of cLBP patients serve as a resource for the larger NIH BACPAC initiative and by contributing scientific expertise, research methods, and leadership to BACPAC.