Manipulating antibody production to maximise memory in vaccine responses

我们的免疫系统提供对细菌的保护。生殖细胞特异性蛋白(抗体)的分泌是这一防御系统的组成部分，也是几乎所有疫苗的基础。流感和SARS-CoV-2大流行以及未能开发出针对艾滋病毒和疟疾的疫苗，提醒我们迫切需要改进我们的战略。增加我们对我们的身体如何通过专门针对外来结构来保护我们的理解，将揭示成功、合理的疫苗开发的途径。

Our immune system provides protection from germs. The secretion of germ-specific proteins (antibodies) is an integral component of this defence and the basis of virtually all vaccines. Pandemics of Influenza and SARS-CoV-2 and failure to develop vaccines against HIV and Malaria remind us that our strategies need urgent improvement. Increasing our understanding of how our body defends us by specifically targeting foreign structures will reveal avenues for successful, rational vaccine development.