Hematopoiesis Training Grant

描述（由申请人提供）：本申请要求更新造血训练补助金，该补助金成立于1999年，旨在解决对造血和造血干细胞生物学有职业兴趣的科学家和医生科学家培训机会短缺的问题;并为下一代提供这一不断发展的学科的核心科学领导。造血计划是一个多学科，跨部门的培训计划，利用宾夕法尼亚大学医学院（PSOM），宾夕法尼亚儿童医院（CHOP）和Wistar研究所的广泛资源;从参加各种博士前和博士后课程的高素质学员中选择被任命者;并包括教师培训人员与广泛的资金，出版物，并指导成就。造血计划培养了17名博士后和5名博士前科学家，拥有博士，医学博士或MD-PHD学位，目前可容纳另外3名博士后和3名博士前任命者。该计划吸引了来自PSOM大型和备受推崇的博士和MD-PhD课程的博士前候选人;以及来自PSOM和CHOP竞争性血液学奖学金计划以及全国领先实验室的博士后申请人。研究导师是由24个科学和经验多样化的培训师提供的，他们的研究兴趣几乎涵盖了造血的所有领域。该计划的学术要素包括课程，研讨会，实验室工作，指导和职业咨询，演示文稿，手稿和赠款写作的综合课程，这些课程有效地结合起来，以培养新的造血科学基础研究人员。根据书面和口头陈述、个性化发展计划以及与PI/PD以及研究和计划导师的情况会议对学员进行评估。这种教学方法的成功是由谁进步到学术界和工业界的领导地位，已成功资助以下程序毕业的被任命者的数量表示，并已作出重大贡献的生物医学文献。造血计划在其前PI/PD去世后，于2011年经历了领导层的变化，促使对计划目标和政策进行全面审查，这些目标和政策加强了培训经验，预计将影响未来的成果评价。该审查还确定了大量高素质的博士前MD-PhD学生在宾夕法尼亚大学与造血的职业兴趣;因此，本申请要求专门为这些合并学位的学生增加两个职位，以鼓励和支持他们在这一领域的职业发展。总之，造血计划是精心设计的，以培养个人在造血的基本原理，在人类生物学的这一重要和不断增长的领域发展研究领导的目标。

DESCRIPTION (provided by applicant): This application requests a renewal of the Hematopoiesis Training Grant, which was founded in 1999 to address the shortage in training opportunities for scientists and physician-scientists with career interests in hematopoiesis and hematopoietic stem cell biology; and to provide a core scientific leadership in this growing discipline for the next generation. The Hematopoiesis Program is a multi-disciplinary, cross-departmental training program that capitalizes on the extensive resources of the University of Pennsylvania School of Medicine (PSOM), The Children's Hospital of Pennsylvania (CHOP), and the Wistar Institute; selects appointees from pools of highly qualified trainees enrolled in their various pre- and post-doctoral programs; and encompasses faculty trainers with extensive funding, publication, and mentoring achievements. The Hematopoiesis Program has trained 17 post-doctoral and 5 pre-doctoral scientists with PhD, MD, or MD-PHD degrees, and currently accommodates an additional 3 post-doctoral and 3 pre-doctoral appointees. The Program draws pre-doctoral candidates from the large and highly regarded PhD and MD-PhD programs at the PSOM; and post-doctoral applicants from the competitive hematology fellowship programs at PSOM and CHOP, and from leading laboratories throughout the nation. Research mentorship is provided by 24 scientifically and experientially diverse trainers with research interests that encompass virtually all areas of hematopoiesis. The academic elements of the Program include an integrated curriculum of coursework, seminars, laboratory work, mentoring and career counseling, presentation, and manuscript and grant writing, which are effectively combined to train new investigators in the fundamentals of hematopoiesis science. Trainees are evaluated on the basis of written and oral presentations, Individualized Development Plans, and status conferences with the PI/PD and both research and Program mentors. The success of this instructional approach is indicated by the number of appointees who have progressed to leadership positions in academia and industry, have been successfully funded following Program graduation, and have made significant contributions to the biomedical literature. The Hematopoiesis Program underwent a change in leadership in 2011 following the death of its previous PI/PD, prompting a comprehensive review of programmatic goals and policy that have strengthened the training experience and are expected to impact future outcomes evaluation. The review also identified a large pool of highly qualified pre-doctoral MD-PhD students at Penn with career interests in hematopoiesis; consequently, this application requests two additional positions that are dedicated to these combined-degree students, to encourage and support their career progression in this area. In sum, the Hematopoiesis Program is carefully designed to train individuals in the fundamentals of hematopoiesis, with a goal of developing research leadership in this important and growing area of human biology.