Core B - Biospecimens

爱荷华州神经内分泌肿瘤（NET）孢子生物标本核心提供了一个协调的，集中的， 专门负责从我们的爱荷华州患者中采集、处理和注释生物标本 神经内分泌肿瘤登记处和SEER残留组织库。的首要目标 生物标本核心是获取神经内分泌肿瘤患者的各种生物标本。 这些标本将包括来自已签署爱荷华州NET的患者的新鲜或快速冷冻标本 获得登记研究同意书以及去识别的福尔马林固定石蜡包埋（FFPE）标本 通过监测流行病学和最终结果（SEER）残留组织储存库（RTR）。所有 样本将在优化其分子研究效用的条件下进行跟踪和储存， 爱荷华州NETSPORE研究人员已经获得了大量的各种各样的NET肿瘤，正常的， 和生殖细胞样本。 所有生物标本将按照既定的程序收集、跟踪并分发给SPORE研究人员。 霍尔顿综合癌症中心（HCCC）的爱荷华州肿瘤采购核心（TPC）方案 还有爱荷华州的预言家所有标本的采集和处理都在严格的质量控制下进行， 分发给SPORE研究人员或存储用于未来的SPORE研究项目。核心追踪 采集、分发和对这些标本获得的结果，允许与临床和其他 在研究项目中收集的数据。核心受益于人道主义协调中心的专门知识，但不重复 其服务。核心支持每个完整的和发展的项目。进行了广泛 利用这些生物样本以及我们的爱荷华州NET数据库中已有的临床和表型数据。 我们将继续积累新的患者样本以及储存库FFPE标本，并将继续 与研究人员合作，利用这一日益宝贵的资源来治疗这些孤儿肿瘤。 生物样本核心的具体目标是：1）收集、处理、储存和分发多余的外科手术样本。 已签署同意书的患者和家庭成员的样本和/或血液/口腔拭子 参与爱荷华州NET登记; 2）获取、处理和分发去识别的神经内分泌肿瘤 通过爱荷华州虚拟肿瘤储存库和SEER残留组织储存库获得的FFPE标本; 3)根据北美神经内分泌标准对所有肿瘤标本进行准确诊断和分级 肿瘤学会（NANETS）指南; 4）与生物统计学和生物信息学核心合作维护数据 从爱荷华州NET登记处和SEER储存库获得生物标本，以进一步合作 研究导致NET患者的长期结局改善。

The Iowa Neuroendocrine Tumor (NET) SPORE Biospecimens Core provides a coordinated, centralized, and dedicated core for the procurement, processing and annotation of biospecimens from patients in our Iowa Neuroendocrine Tumor Registry and also from SEER Residual Tissue Repositories. The primary goal of the Biospecimens Core is to procure a variety of biologic specimens on patients with neuroendocrine tumors. These specimens will include fresh or rapidly frozen specimens from patients who have signed the Iowa NET Registry consent as well as de-identified, formalin-fixed paraffin-embedded (FFPE) specimens obtained through the Surveillance Epidemiology and End Results (SEER) residual tissue repository (RTR). All specimens will be tracked and stored under conditions that optimize their utility for molecular studies, assuring the Iowa NET SPORE investigators have access to a large number of a wide variety of NET tumor, normal, and germline specimens. All biospecimens will be collected, tracked and distributed to SPORE researchers following the established protocols of the Iowa Tumor Procurement Core (TPC) in the Holden Comprehensive Cancer Center (HCCC) and the Iowa SEER. All specimens are collected and processed under tight quality control, tracked and distributed to SPORE researchers or banked for future SPORE research projects. The Core tracks the acquisition, distribution, and results obtained on these specimens, allowing integration with clinical and other data collected in research projects. The Core benefits from the expertise in the HCCC, but does not duplicate its services. The Core supports each of the full and developmental projects. There has been extensive utilization of these biospecimens with resulting clinical and phenotypic data already in our Iowa NET Database. We will continue to accrue new patient samples as well as repository FFPE specimens and will continually work with investigators to utilize this increasingly valuable resource for these orphan tumors. Specific Aims of the Biospecimens Core are: 1) Collect, process, bank and distribute excess surgical specimens and/or blood/buccal swabs from patients and family members who have signed consent to participate in the Iowa NET Registry; 2) Acquire, process, and distribute de-identified neuroendocrine tumor FFPE specimens obtained through the Iowa Virtual Tumor Repository and SEER Residual Tissue Repository; 3) Provide accurate diagnosis and grade on all tumor specimens according to North American Neuroendocrine Tumor Society (NANETS) guidelines; 4) Work with the Biostatistics and Bioinformatics Core to maintain data obtained from Iowa NET Registry biospecimens and SEER Repository biospecimens to further collaborative research leading to improved long term outcomes for patients with NETs.