ShEEP Request for VA BIC MRI Cryoprobe

我们正在申请资金为我们现有的Bruker 7购买Bruker MRI CryoProbe升级 特斯拉小孔核磁共振基于供应商报价的成本为542,358美元。此次升级包括 与Bruker Biosect 7Tesla/20磁体兼容的4元件阵列低温探头。这个 升级将包括支持由风冷He压缩机组成的硬件基础设施 耦合到氦气压缩机控制器，该控制器直接连接到低温冷却单元 为低温探测器装置提供液氦。CryoProbe将提供2到5倍的增长 在系统灵敏度(信噪比)中，允许我们采集数据以产生扩散张量 用于评估神经炎症和白质完整性的成像(DTI)图 在创伤性脑损伤(TBI)啮齿动物模型中。这项技术不仅将扩大我们的 神经成像能力，但将被用作神经成像评估的关键组件 结合临床前脑外伤模型的PET和SPECT神经成像数据 和创伤后应激障碍，以支持杜鲁门退伍军人医院新建立的开阔场地爆炸核心。 除了极大地增强我们的神经成像能力外，冷冻探头技术的添加 还将支持正在进行的尖端心血管和热疗核技术的扩展 与退伍军人护理直接相关的肿瘤学研究项目。

We are requesting funds to purchase a Bruker MRI Cryoprobe upgrade for our existing Bruker 7 Tesla small bore MRI based on the vendor quoted cost of $542,358. The upgrade is comprised of a 4 Element Array Cryoprobe compatible with a Bruker Biospect 7Tesla/20 magnet. The upgrade will include supporting hardware infrastructure comprised of an air cooled He compressor coupled to a Helium Compressor Controller that is linked directly to the Cryo Cooling Unit supplying liquid helium to the Cryoprobe device. The Cryoprobe will provide a 2 to 5 fold increase in system sensitivity (signal/noise ratio) permitting us to acquire data to generate Diffusion Tensor Imaging (DTI) maps for the assessment of neuroinflammation and the integrity of white matter tracts in rodent models of Traumatic Brain Injury (TBI). This technology will not only expand our neuroimaging capabilities but will be utilized as a critical component for neuroimaging assessment when coupled with PET and SPECT neuroimaging data obtained from preclinical models of TBI and PTSD in support of the newly established Open Field Blast Core at the Truman VA Hospital. Beyond greatly enhancing our neuroimaging capabilities, the addition of cryoprobe technology will also support expansion of ongoing cutting edge cardiovascular and theranostic nuclear oncology research programs directly related to veteran care.