Manufacture and Testing of Next Generation Orthopaedic Implants Harnessing Periosteum's Regenerative Power

组织缺陷，例如由于创伤或肿瘤切除，太大，不进行重建手术就无法愈合。与缺损修复相关的并发症可能降低患者的生活质量和生产力，造成重大的医疗和社会心理成本。在这里，我们提出了一个计划，为下一代“智能”骨科植入物定义技术规范，这些植入物可以传递细胞和它们需要使用自然范式构建新组织的信号。

Tissue defects, e.g. due to trauma or tumor removal, are too large to heal without reconstructive surgery. Complications associated with defect repair may diminish the patient's quality of life and productivity, posing significant medical and psychosocial costs. Here we propose a plan to define technical specifications for next generation, 'smart' orthopaedic implants that deliver cells and the signals they need to build new tissue using nature's paradigms.