Manufacture and Testing of Next Generation Orthopaedic Implants Harnessing Periosteum's Regenerative Power

组织缺损，例如由于创伤或肿瘤切除，太大而不能在没有重建手术的情况下愈合。与缺陷修复相关的并发症可能会降低患者的生活质量和生产力，造成重大的医疗和心理社会成本。在这里，我们提出了一个计划，以定义下一代的技术规格，“智能”骨科植入物，提供细胞和信号，他们需要建立新的组织使用自然的范例。

Tissue defects, e.g. due to trauma or tumor removal, are too large to heal without reconstructive surgery. Complications associated with defect repair may diminish the patient's quality of life and productivity, posing significant medical and psychosocial costs. Here we propose a plan to define technical specifications for next generation, "smart" orthopaedic implants that deliver cells and the signals they need to build new tissue using nature's paradigms.