Evaluating How Tobacco Control Policies are Shaping the Nicotine Delivery Market

描述（由申请人提供）：许多国家对新一代汽化尼古丁产品（VNPs）的需求迅速增长，表明这些产品正在对卷烟消费产生影响。VNPs的具体影响以及公共卫生政策如何塑造VNPs和烟草使用行为是需要回答的关键问题。该计划项目的目标是扩展国际烟草控制政策评估项目（ITC项目）的工作，以确定当前和未来潜在的VNP监管政策的有效性。这个项目的时机是合适的，因为监管VNPs的政策正在演变，需要数据来帮助指导政策制定。拟议中的研究是基于这样的信念，即要彻底评估调控VNPs的政策，必须在受控的实验条件下，在人口水平和个人水平上这样做。所描述的多方法方法将在美国（US）、英国（EN）和加拿大（CA）这三个国家进行，因为每个国家都有类似的吸烟率和卷烟产品法规的历史，但对VNP的监管政策不同。拟议的五项相互关联的研究和两项核心服务涉及三个总体目标：1）更全面地了解政策环境如何影响吸烟和从吸烟到VNP的过渡。研究小组将对具有广泛代表性的成人和青少年样本进行自然主义研究（项目1和3）和对汽化尼古丁市场的监测（项目2）允许研究国家之间和国家内部的政策效应，并将这些数据与实验研究的数据相结合，这些实验研究旨在测试理论政策选择如何影响非吸烟青年对VNP的需求（项目3）和成年吸烟者（项目4）; 2）促进开发监测对VNP和未来替代尼古丁产品反应的方法。该小组将调查数据收集方法的差异（项目1和2），研究样品（项目1、3和4）和实验方案（项目3和4）以了解哪些方法最具成本效益，并为实际应用提供最高质量的数据，以预测对政策变化的反应;制定方法，协助决策者预测不同产品监管计划对人口健康的影响。在项目5中，该小组将整合来自观察性研究（项目1、2和3）和实验性研究（项目3和4）的数据，以及其他数据，以模拟不同政策对人口健康结果的影响。总的来说，拟议的研究全面探讨了不同的VNP政策环境是如何影响VNP和吸烟行为在真实的世界和测量的影响，在实验设置的理论政策选择。这一政策研究整体计划的最终产品将是一个独特的多国证据库，具有很强的潜力，为美国、欧盟和加拿大以及其他国家的政策和法规提供信息。

DESCRIPTION (provided by applicant): The rapidly growing demand for a new generation of vaporized nicotine products (VNPs) seen in many countries suggests these products are having an impact on cigarette consumption. The specific impact that VNPs are having and how VNPs and tobacco use behaviors are being shaped by public health policies are key questions that need to be answered. The goal of this Program Project is to extend the work of the International Tobacco Control Policy Evaluation Project (ITC Project) to characterize the effectiveness of current and potential future policies to regulate VNPs. The timing of this project is opportune since policies regulating VNPs are evolving, and data are needed to help guide policy development. The proposed research is premised on the belief that to thoroughly assess policies regulating VNPs it is essential to do so at both the population level and at the individua-level under controlled experimental conditions. The multi-method approach described will be carried out in three countries - United States (US), England (EN), and Canada (CA)- selected because each have similar smoking rates and histories of cigarette product regulations, but divergent policies regulating VNPs. The proposed set of five inter-related studies and two core services addresses three overall aims: 1) To provide a more thorough understanding of how the policy environment influences uptake of and transitions from smoked tobacco to VNPs. The research team will implement naturalistic studies of broadly representative adult and adolescent samples (Projects 1 & 3) and surveillance of the vaporized nicotine market (Project 2) to allow between country and within-country policy effects to be studied and combining these data with data from experimental studies testing how theoretical policy options might affect the demand for VNPs in nonsmoking youth (Project 3) and adult smokers (Project 4); 2) To contribute to the development of methods for monitoring response to VNPs and future alternative nicotine products. The team will investigate differences in methods in data collection (Projects 1 & 2), study samples (Projects 1, 3 & 4), and experimental protocols (Projects 3 & 4) to see which approaches are most cost-efficient and yield the highest quality data for real-world applications in predicting responses to policy changes; and 3) To develop methods to assist policymakers in forecasting the population health impact of different product regulatory schemes. In Project 5 the group will integrate the data from observational (Projects 1, 2 & 3) and experimental studies (Projects 3 & 4), plus additional data, to model the impact of different policies on population health outcomes. Collectively, the proposed studies comprehensively examine how different VNP policy environments are influencing VNP and smoked tobacco use behaviors in the real world and the measured impact of theoretical policy options in the experimental setting. The end product of this holistic program of policy research will be a unique, multi-country evidence base with strong potential to inform policies and regulations in the US, EN, and CA and perhaps other countries as well.