2020 Signal Transduction in Microorganisms Gordon Research Conference and Gordon Research Seminar

项目摘要 2020年戈登微生物感官转导研究会议将在加利福尼亚州文图拉举行 将探索了解细菌（尤其是病原体）信号转导的最新进展。重点将 置于化学感应和群体感应机制和途径，小分子细胞内 信号（例如c-di-GMP和其他环核苷酸，ppGpp），双组分系统和细胞 它们调节的过程以及细菌生活方式决定的机制，包括生物膜、细菌 多细胞行为和捕食者-猎物相互作用。这些系统在发病机制中的作用 和抗生素耐药性将成为中心主题。本次会议的一个新设计的主题将是主办- 微生物相互作用，包括细菌第二信使和宿主免疫之间的相互作用 系统所有这些关键领域都将通过分子遗传学、细胞遗传学和细胞生物学的前沿应用得到解决。 生物学、生物化学和化学生物学以及结构、成像、生物物理和计算 接近。来自高分辨率实验的数据将与建模配对，以了解和预测 复杂大分子组装和信号电路的行为。演讲嘉宾将包括 已建立的和早期的调查人员。此外，海报展示者将竞争简短的演讲。 与会者将受益于会议的开放，合议的气氛，提供了独特的机会， 参与科学讨论，促进科学严谨性，促进跨学科合作。第三 届时，一个戈登研究研讨会（GRS）的博士后和研究生将之前的GRC。档案处 为年轻科学家提供了一个支持性的环境，让他们展示自己的工作，并接受领导者的建议， 外地长期以来，STIM社区一直支持年轻科学家，我们认为GRS的成功是一个成功的例子。 继续执行这个使命的必要性GRS将帮助我们不仅培养早期阶段的发展， 调查员，但也促进我们社区内的多样性。GRS将帮助年轻科学家获得 信心和技能，成为成熟的GRC参与者。整合良好的STIM GRC/GRS将指导 建立调查员面临的最重要的问题，我们的领域，并将鼓励年轻 科学家们将他们最近的训练应用到令人兴奋的微生物学新领域。

Project summary The 2020 Gordon Research Conference on Sensory Transduction in Microorganisms to be held in Ventura, CA will explore recent advances in understanding signal transduction in bacteria, especially pathogens. Focus will be placed on chemosensory and quorum sensing mechanisms and pathways, small molecule intracellular signals (e.g. c-di-GMP and other cyclic nucleotides, ppGpp), two component systems and the cellular processes they regulate as well as mechanisms of bacterial lifestyle decisions including biofilms, bacterial multicellular behavior and predator-prey interactions. The roles of these systems with respect to pathogenesis and antimicrobial resistance will be central themes. A newly designed topic for this conference will be host- microbe interactions including the interplay between bacterial second messengers and the host immune system. All these critical areas will be addressed through cutting-edge applications of molecular genetics, cell biology, biochemistry, and chemical biology as well as structural, imaging, biophysical, and computational approaches. Data from high-resolution experiments will be paired with modeling to understand and predict the behavior of complex macromolecular assemblies and signaling circuitry. Invited speakers will include both established and early-stage investigators. In addition, poster presenters will compete for short talks. Participants will benefit from the Conference's open, collegial atmosphere that provides unique opportunities to engage in scientific discussion, promote scientific rigor, and foster interdisciplinary collaboration. For the third time, a Gordon Research Seminar (GRS) for postdocs and graduate students will precede the GRC. The GRS provides a supportive environment for young scientists to present their work and receive advice by leaders in the field. The STIM community has long supported junior scientists, and we view the success of the GRS as a necessity to continue on this mission. The GRS will help us not only nurture the development of early stage investigators, but also promote diversity within our community. The GRS will help junior scientists gain the confidence and skills to become full-fledged GRC participants. The well-integrated STIM GRC/GRS will direct established investigators to the most important questions confronting our field and will encourage young scientists to apply their recent training to the exciting new areas of microbiology.