Superfund Training Core

摘要：跨学科研究仍然是美国国立卫生研究院路线图的一个重要特征。路易斯维尔对化学品的综合调查将解决暴露对与心脏代谢性疾病有关的健康后果的影响。UofL Superfund危险物质研究和培训项目的中心假设是，暴露在环境化学品、挥发性有机化合物(VOCs)中会导致/加剧胰岛素抵抗，导致心脏代谢性疾病。我们生物医学项目的初步结果提供了证据，表明肥胖使个人面临与VOCs暴露相关的不良健康后果的更高风险，而我们的非生物医学项目将解决缺乏系统测量工业区远近居民接触这些化学物质的方法的问题。这一培训核心将培训我们的博士后和博士后研究员，不仅是在实验室基础上的研究，而且还将培训我们与超级基金研究项目中的其他人以及整个社区有效地沟通研究结果。培训核心将为我们的学员开发研究生课程，与密歇根大学工程、牙科、医学和护理学院以及艺术与科学学院共享，提供有关挥发性有机化合物对化学和人体健康影响的最新信息。培训中心还将为专业和本科培训项目做出贡献，为加州大学伯克利分校生物和化学本科生荣誉学生、护理、牙科和医学学生以及杰斐逊县学校系统的教师和高中生提供研讨会演讲者或讲师，向他们介绍化学物质暴露在人类疾病中的作用。最后，我们的学员将与西路易斯维尔特别工作组和大都会路易斯维尔公共卫生和健康部门以及我们的社区参与和研究翻译中心一起参加会议，参与讨论并回答有关超级基金研究项目的问题。每个受训人员将被分配一个具体的项目，每个受训人员将开发该项目，以体验如何将研究成果转化为能够有效地传达给社区、各种地方/州机构和大学观众的概念。

Abstract: Interdisciplinary research remains an important feature of the NIH Roadmap. An integrated investigation of chemicals in Louisville will address the effects of exposure on health outcomes related to cardiometabolic disease. The central hypothesis of the UofL Superfund Hazardous Substance Research and Training Project is that exposure to the environmental chemicals, volatile organic compounds (VOCs) causes/exacerbates insulin resistance, leading to cardio-metabolic disease. Preliminary results from our biomedical projects provide evidence that obesity places individuals at higher risk to adverse health outcomes related to VOCs exposures, while our non-biomedical projects will address the lack of methods to systematically measure exposure to these chemicals in residents distal and proximal to industrial areas. This Training Core will train our pre- and post-doctoral fellows not only in laboratory-based research, but also in effective communication of the research findings to others in the Superfund Research Projects, as well as to the Community at large. The Training Core will develop graduate courses for our Trainees to be shared with the UofL Schools of Engineering, Dentistry, Medicine and Nursing and the College of Arts & Sciences, providing the latest information about the chemistry and human health effects of volatile organic compounds. The Training Core also will contribute to the professional and undergraduate training programs by providing our trainees as seminar speakers or lecturers to UofL undergraduate Biology & Chemistry honors students, to nursing, dentistry, and medical students, and to teachers and high school students in the Jefferson County School System to communicate the role of chemical exposure in human disease. Finally, our trainees will participate in meetings with the West Louisville Task Force and the Metro Louisville Public Health and Wellness Department with our Community Engagement and Research Translation Cores to engage in discussion and answer questions about the Superfund research projects. Each trainee will be assigned a specific project that each trainee will develop in order to experience how to translate research findings into concepts that can be transmitted effectively to the community, various local/state agencies, and university audiences alike.