Hepatobiology and Toxicology COBRE

? 描述（由申请人提供）：路易斯维尔大学（UofL）肝脏生物学和毒理学COBRE是一个独特的主题研究中心。UofL COBRE科学家由一个多学科小组高级导师和初级研究人员组成，专注于肝损伤，营养和肠道的机制和治疗：肝脏相互作用，以及肝脏：环境/毒素/药物相互作用。肝脏是人体内最大的内脏器官，也可能是最复杂的 从新陈代谢的角度来说。非酒精性脂肪性肝病/非酒精性脂肪性肝炎（NAFLD/NASH）是最常见的肝病，影响美国约1/3的成人和超过10%的儿童。NAFLD在超重/肥胖个体中最常见，并且与代谢综合征高度相关。酒精性肝病（ALD）仍然是饮酒者的常见问题。环境毒物引起的肝损伤是一个越来越被认识到的问题，路易斯维尔一直是这一领域的领导者。B型和C型肝炎仍然是全世界肝硬化和肝细胞癌（HCC）的重要原因。个性化医疗是影响药物疗效的一个越来越重要的因素。药物性肝损伤（DILI）是药物从市场上撤下的最常见原因，也是肝衰竭的重要原因。这个COBRE汇集了来自UofL的经验丰富的高级导师和有前途的初级研究人员，与美国各地的科学家合作。世界肝脏生物学和毒理学的独特主题进行交叉研究。肝脏生物学和毒理学COBRE的具体目标是：1。开发一个以肝脏生物学和毒理学为主题的计划，加强UofL的整体研究基础设施。2.创建一个多学科的研究教育计划，指导和职业发展在肝生物学和毒理学。3.提供必要的研究资源和转化科学/基础技术，以支持和维持肝脏生物学和毒理学的最新研究。4.发现预防和/或治疗肝脏疾病/有毒物质暴露的新机制/分子靶点和有效方法，并将我们的发现传达给公众。

? DESCRIPTION (provided by applicant): The University of Louisville (UofL) Hepatobiology and Toxicology COBRE is a unique thematic research center. The UofL COBRE scientists comprise a multidisciplinary group senior mentors and junior investigators focusing on the mechanisms and therapy for liver injury, nutrition and gut:liver interactions, and liver:environment/toxin/dru interactions. The liver is the largest internal organ in the body, and is possibly the most complex organ in terms of metabolism. Non-alcoholic fatty liver disease/non-alcoholic steatohepatitis (NAFLD/NASH) is the most common liver disease, affecting about 1/3 of adults and over 10% of children in the US. NAFLD arises most commonly among overweight/obese individuals, and is highly linked to the Metabolic Syndrome. Alcoholic Liver Disease (ALD) remains a common problem among those who drink. Environmental Toxicant Induced Liver Injury is an increasingly recognized problem, and Louisville has been a leader in this area. Hepatitis B and C remain important causes of cirrhosis and hepatocellular carcinoma (HCC) worldwide. Personalized Medicine is an increasingly important factor in medication efficacy. Drug-Induced Liver Injury (DILI) is the most common reason drugs are removed from the market and an important cause of liver failure. This COBRE brings together experienced senior mentors and promising junior investigators from across UofL in collaboration with scientists across the U.S./World to perform cross-cutting research on the unique topics of Hepatobiology and Toxicology. The Specific Aims of the Hepatobiology and Toxicology COBRE are to: 1. Develop a thematically-focused program in Hepatobiology and Toxicology that strengthens the overall research infrastructure at UofL. 2. Create a multidisciplinary program in research education, mentoring and career development in Hepatobiology and Toxicology. 3. Provide the necessary research resources and translational science/basic technologies to support and sustain state-of-the-art research in Hepatobiology and Toxicology. 4. Discover new mechanisms/molecular targets and effective means for preventing and/or treating liver diseases/toxicant exposures and communicate our findings to the public.