Exercise training to improve cognitive function_523_Sparrow

项目背景/理由。阿尔茨海默病（AD）困扰着近600万美国人， 预计在未来几十年内将继续增长。已知AD具有较长的临床前阶段，其中病理生理学改变可导致AD的发病。 这些过程在临床症状出现之前多年甚至数十年发展。在本临床前研究期间， 有证据表明，在第一阶段，认知功能持续下降，特别是在情景记忆中。到目前为止， 药物干预减缓认知功能下降的有效性的证据已经被 有限，导致对包括运动在内的非药物干预效用的兴趣日益增加。 项目目标。我们建议评估一种新的以家庭为基础的运动干预的可行性， 改善情景记忆，使用阻力训练结合远程提供的实时指导， 60名50岁或以上轻度认知障碍的个体。关于结果测量的初步数据 （Rey-Osterrieth复杂图形测试，Wechsler逻辑记忆测试），潜在的中介（胰岛素样生长 因子-1），并将获得潜在的调节剂（载脂蛋白E14）。 项目方法。我们将估计干预组（n=30）和对照组（n=30）之间的差异 6个月时情景记忆的变化（Rey-Osterrieth复杂图形测试、Wechsler逻辑记忆测试） 以及效应量，这将用作拟议的更大研究的样本量计算的基础。 此外，我们将探讨6个月期间血清胰岛素样生长因子-1浓度的变化， 抗阻训练计划作为一个潜在的中介运动相关的情节记忆的变化。此外，本发明还 我们将探讨载脂蛋白E144携带状态（携带者/非携带者）作为潜在的调节因素。

Project Background/Rationale. Alzheimer's disease (AD) afflicts nearly 6 million Americans, a number projected to grow in coming decades. AD is known to have a long preclinical phase in which pathophysiologic processes develop many years, even decades, before the onset of clinical symptoms. During this preclinical phase there is evidence of unremitting decline in cognitive function, particularly in episodic memory. Thus far, evidence of the efficacy of pharmacological interventions to slow this decline in cognitive function has been limited, leading to increasing interest in the utility of nonpharmacological interventions including exercise. Project Objectives. We propose to assess the feasibility of a novel home-based exercise intervention to improve episodic memory that uses resistance training coupled with real-time guidance delivered remotely in 60 individuals 50 years of age or older with mild cognitive impairment. Preliminary data on outcome measures (Rey-Osterrieth Complex Figure Test, Wechsler Logical Memory Test), a potential mediator (insulin-like growth factor-1), and a potential moderator (apolipoprotein EƐ4) will be obtained. Project Methods. We will estimate the difference between the intervention (n=30) and the control group (n=30) on 6-month change in episodic memory (Rey-Osterrieth Complex Figure Test, Wechsler Logical Memory Test) as well as the effect size, which will be used as a basis for sample size calculation for a proposed larger study. In addition, we will explore 6-month change in serum insulin-like growth factor-1 concentration during the resistance exercise program as a potential mediator of exercise-related changes in episodic memory. Further, we will explore apolipoprotein EƐ4 carrier status (carrier/noncarrier) as a potential moderator.