Telephone-linked, home-based exercise training in PD

PD 中的电话连接、家庭运动训练

• 批准号: 9235736
• 负责人: DAVID W. SPARROW
• 金额: --
• 依托单位: VA BOSTON HEALTH CARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9235736
• 关键词: Age-Years; Antidepressive Agents; Caring; Communities; Consensus; Coupled; Disease; Distress; Educational Intervention; Elderly; Exercise; Future; Hamilton Rating Scale for Depression; Health education; Home environment; Intervention; Link; Mental Depression; Methods; Parkinson Disease; Patients; Pharmaceutical Preparations; Pharmacological Treatment; Polypharmacy; Protocols documentation; Questionnaires; Randomized; Randomized Controlled Trials; Resistance; Risk Factors; Safety; Symptoms; Technology; Telephone; Testing; Time; Veterans; Voice; base; depressive symptoms; design; disability; exercise intervention; exercise training; improved; intervention program; motor symptom; non-motor symptom; novel; primary outcome; programs; response; secondary outcome; strength training; virtual

Project Background/Rationale. Depression may be an important component of Parkinson's disease (PD) in many patients, contributing to significant levels of disability and distress. However, there is no consensus on best pharmacological treatment for depression in PD as efficacy is lacking and there is much concern about polypharmacy and safety of various antidepressant medications. Therefore, it is essential that we characterize the effects of nonpharmacological interventions on depression in PD. Several studies reveal significant benefits of exercise in reducing depressive symptoms. Project Objectives. We propose to conduct a randomized, controlled trial of a novel program that uses resistance training coupled with real-time guidance delivered remotely in patients with depression in PD. We hypothesize that patients in the resistance training intervention program will improve on depression scores over 6 months, as compared with patients in the health education program. Project Methods. Community-dwelling veterans with PD and depression will be randomized to the resistance training intervention coupled with real-time guidance or to the health education control intervention. We will test the effects of the exercise intervention over 6 months for the primary outcome of the Hamilton Rating Scale for Depression and for the 2 secondary outcomes of the 39-item Parkinson's Disease Questionnaire and the Unified Parkinson's Disease Rating Scale. Furthermore, we will assess risk factors for compliance with the study protocol to enable us to possibly refine the design of a future large study.

项目背景/理由。抑郁可能是帕金森病（PD）的重要组成部分， 许多病人，造成严重的残疾和痛苦。但是，在以下方面没有达成共识： PD患者抑郁症的最佳药物治疗，因为缺乏疗效， 多种抗抑郁药物的安全性。因此，我们必须将 非药物干预对PD患者抑郁的影响。几项研究显示， 运动对减轻抑郁症状的好处。 项目目标。我们建议进行一项随机对照试验， 阻力训练结合远程实时指导治疗PD抑郁症患者我们 假设参加抗阻训练干预项目的患者抑郁评分会有所改善 6个月以上，与健康教育组比较，差异有统计学意义（P < 0. 05）。 项目方法。社区居住的退伍军人与PD和抑郁症将被随机分配到阻力 培训干预结合实时指导或健康教育控制干预。我们将测试 运动干预6个月对汉密尔顿评定量表主要结局的影响， 抑郁症和39项帕金森病问卷的2个次要结局以及 帕金森氏病统一评定量表。此外，我们将评估遵守 研究方案，使我们能够完善未来大型研究的设计。