Telephone-linked, home-based exercise training in PD

PD 中的电话连接、家庭运动训练

• 批准号: 9235736
• 负责人: DAVID W. SPARROW
• 金额: --
• 依托单位: VA BOSTON HEALTH CARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9235736
• 关键词: Age-Years; Antidepressive Agents; Caring; Communities; Consensus; Coupled; Disease; Distress; Educational Intervention; Elderly; Exercise; Future; Hamilton Rating Scale for Depression; Health education; Home environment; Intervention; Link; Mental Depression; Methods; Parkinson Disease; Patients; Pharmaceutical Preparations; Pharmacological Treatment; Polypharmacy; Protocols documentation; Questionnaires; Randomized; Randomized Controlled Trials; Resistance; Risk Factors; Safety; Symptoms; Technology; Telephone; Testing; Time; Veterans; Voice; base; depressive symptoms; design; disability; exercise intervention; exercise training; improved; intervention program; motor symptom; non-motor symptom; novel; primary outcome; programs; response; secondary outcome; strength training; virtual

Project Background/Rationale. Depression may be an important component of Parkinson's disease (PD) in many patients, contributing to significant levels of disability and distress. However, there is no consensus on best pharmacological treatment for depression in PD as efficacy is lacking and there is much concern about polypharmacy and safety of various antidepressant medications. Therefore, it is essential that we characterize the effects of nonpharmacological interventions on depression in PD. Several studies reveal significant benefits of exercise in reducing depressive symptoms. Project Objectives. We propose to conduct a randomized, controlled trial of a novel program that uses resistance training coupled with real-time guidance delivered remotely in patients with depression in PD. We hypothesize that patients in the resistance training intervention program will improve on depression scores over 6 months, as compared with patients in the health education program. Project Methods. Community-dwelling veterans with PD and depression will be randomized to the resistance training intervention coupled with real-time guidance or to the health education control intervention. We will test the effects of the exercise intervention over 6 months for the primary outcome of the Hamilton Rating Scale for Depression and for the 2 secondary outcomes of the 39-item Parkinson's Disease Questionnaire and the Unified Parkinson's Disease Rating Scale. Furthermore, we will assess risk factors for compliance with the study protocol to enable us to possibly refine the design of a future large study.

项目背景/理由。抑郁症可能是帕金森氏病（PD）的重要组成部分 许多患者，导致大量残疾和困扰水平。但是，没有达成共识 由于缺乏功效，最佳的PD抑郁症药理治疗 各种抗抑郁药的多药和安全性。因此，我们必须描述 非药物干预措施对PD抑郁症的影响。几项研究揭示了显着的 减轻抑郁症状的运动的好处。 项目目标。我们建议对一个新颖程序进行随机，对照试验，该试验使用 电阻训练以及PD抑郁症患者远程提供的实时指导。我们 假设抵抗训练干预计划中的患者将在抑郁评分上有所改善 与健康教育计划中的患者相比，超过6个月。 项目方法。具有PD和抑郁症的社区居民退伍军人将被随机分配给抵抗 培训干预措施以及实时指导或健康教育控制干预措施。我们将测试 汉密尔顿评级量表的主要结果超过6个月的运动干预措施的影响 抑郁症以及39个项目帕金森氏病问卷的两个次要结果和 统一的帕金森氏病评级量表。此外，我们将评估符合符合的风险因素 研究方案使我们能够完善未来大型研究的设计。