Telephone-linked, home-based exercise training in PD

项目背景/基本原理。抑郁可能是帕金森病(PD)的一个重要组成部分 许多患者，导致严重的残疾和痛苦。然而，关于这一点并没有达成共识。 帕金森病患者抑郁的最佳药物治疗，因为缺乏疗效，人们对 多药并存和各种抗抑郁药物的安全性。因此，我们必须将 非药物干预对帕金森病患者抑郁的影响几项研究揭示了重要的 运动对减少抑郁症状的好处。 项目目标。我们建议对一种新的程序进行随机对照试验，该程序使用 阻力训练结合实时指导对帕金森病抑郁患者进行远程指导。我们 抵抗训练干预计划中的患者将改善抑郁评分的假设 6个月以上，与健康教育方案中的患者相比。 项目方法。患有帕金森氏症和抑郁症的社区居住退伍军人将被随机分配到抵抗组织中 培训干预结合实时指导或对健康教育进行控制干预。我们将测试 运动干预6个月以上对儿童汉密尔顿量表主要结果的影响 抑郁和39个项目的帕金森病问卷的两个次要结果和 统一的帕金森氏病评定量表。此外，我们将评估遵守 研究方案，使我们有可能改进未来大型研究的设计。

Project Background/Rationale. Depression may be an important component of Parkinson's disease (PD) in many patients, contributing to significant levels of disability and distress. However, there is no consensus on best pharmacological treatment for depression in PD as efficacy is lacking and there is much concern about polypharmacy and safety of various antidepressant medications. Therefore, it is essential that we characterize the effects of nonpharmacological interventions on depression in PD. Several studies reveal significant benefits of exercise in reducing depressive symptoms. Project Objectives. We propose to conduct a randomized, controlled trial of a novel program that uses resistance training coupled with real-time guidance delivered remotely in patients with depression in PD. We hypothesize that patients in the resistance training intervention program will improve on depression scores over 6 months, as compared with patients in the health education program. Project Methods. Community-dwelling veterans with PD and depression will be randomized to the resistance training intervention coupled with real-time guidance or to the health education control intervention. We will test the effects of the exercise intervention over 6 months for the primary outcome of the Hamilton Rating Scale for Depression and for the 2 secondary outcomes of the 39-item Parkinson's Disease Questionnaire and the Unified Parkinson's Disease Rating Scale. Furthermore, we will assess risk factors for compliance with the study protocol to enable us to possibly refine the design of a future large study.