Telemedicine intervention in patients with chronic pain in PD

PD慢性疼痛患者的远程医疗干预

• 批准号: 10532427
• 负责人: DAVID W. SPARROW
• 金额: --
• 依托单位: VA BOSTON HEALTH CARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-12-01 至 2026-11-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10532427
• 关键词: Address; Age Years; Analgesics; Brief Pain Inventory; Caring; Cognition; Cognitive; Communities; Complex; Concept Formation; Controlled Study; Disease; Exercise; Future; Guidelines; Health education; Home; Individual; Intervention; Mediating; Mediation; Methods; Pain; Pain interference; Pain management; Parkinson Disease; Patients; Physical Exercise; Physical activity; Physical therapy; Population; Prevalence; Quality of life; Randomized; Randomized, Controlled Trials; Reporting; Research; Role; Safety; Sample Size; Severities; Technology; Telemedicine; Testing; Training Programs; Veterans; chronic pain; chronic pain management; chronic pain patient; cognitive function; cognitive training; common symptom; coping; design; disabling symptom; efficacy evaluation; executive function; exercise intervention; exercise training; experience; functional improvement; improved; interest; intervention effect; intervention program; non-motor symptom; pain outcome; pain perception; pain reduction; pharmacologic; primary outcome; programs; therapy design; virtual patient

Project Background/Rationale. Pain is one of the most disabling and common nonmotor symptoms in Parkinson’s disease (PD), with a prevalence of 40-85% (Broen et al., 2012). Research indicates that undertreatment of pain is particularly high in the PD population. Only about one-half of patients with PD who report pain receive regular pain medications (Broen et al., 2012; Negre-Pages et al., 2008; Beiske et al., 2009). There is increasing interest in nonpharmacological treatments for chronic pain in PD to supplement pharmacological approaches. While there is evidence to support the utility of physical exercise to improve chronic pain management, relatively less is known about the role of cognitive exercise. Project Objective. We propose to conduct a pilot randomized, controlled trial in patients with chronic pain in PD to assess the impact of physical and cognitive exercise interventions on pain outcomes. Project Methods. A total of 166 community-dwelling veterans, 40 years of age or older, with chronic pain in mild-to-moderate PD will be randomly assigned in a 2 x 2 factorial design to one of four groups (1 – combined cognitive and physical intervention, 2 – physical intervention only, 3 – cognitive intervention only, 4 – health education). We will test the effects of the interventions at 3 months for the outcomes pain severity and pain interference, both assessed with the use of the Brief Pain Inventory.

项目背景/理由。疼痛是最常见的非运动性症状之一