2020 Basal Ganglia Gordon Research Conference and Gordon Research Seminar

项目概要/摘要： 基底神经节是一组错综复杂的相互连接的皮质下大脑区域，它们对大脑的活动至关重要。 行动的动机、选择、发起和执行。与这些作用一致，基底神经节功能障碍 与使人衰弱的精神障碍有关，包括帕金森病、亨廷顿病、肌张力障碍、 成瘾、强迫症和图雷特综合征。基底神经节的重要性 健康和疾病，以及探索其作用的方法的不断发展和演变 和相互作用，激发了不同的研究社区集中在这些结构。尽管越来越多 在首届基底神经节戈登研究会议（GRC）之前， 2014年，唯一一次关注基底神经节的会议是国际基底神经节三年一度的会议， 神经节协会（IBAGS），通常在美国境外举行。此外，IBAGS会议遵循典型的 研讨会的形式，这与互动，讨论为导向的形式的一个集团。以来 2016年，基底神经节GRC已纳入1.5天戈登研究研讨会（GRS）组织 专为博士前和博士后学员开设。从2018年基底神经节GRC和GRS开始， 这些会议现在是两年一次的定期会议。2020年基底神经节GRC和GRS的计划是 由代表该领域基础和临床研究的跨学科委员会设计。蓄意 努力纳入2018年会议未包括的新发言者和主题， 基底神经节：从思想到行动主题包括认知和决策， 基底神经节的细胞可塑性，基底神经节回路内外的相互作用，新的计算 模型和临床相关的步态冻结。 2020年基底神经节GRC和GRS有3个具体目标：1）通过以下方式推进基底神经节研究： 在鼓励提问和讨论的互动环境中展示前沿研究， 挑战当前的思维，确定开放的问题，并提供新的合作机会; 2）模型 基底神经节研究在科学方法和主题，性别平衡，职业阶段， 和少数民族的代表性;和3）提供机会，领导，教育和辅导，为早期 职业科学家这些目标的成功完成将通过鼓励和促进基底神经节的研究， 新的想法和合作，突出该领域的多样性，并激励下一代科学家。 这将加快发现和转化到临床的步伐，与NIH的使命一致。

Project Summary/Abstract: The basal ganglia are an intricately interconnected group of subcortical brain regions that are critical for the motivation, selection, initiation, and execution of actions. Consistent with these roles, basal ganglia dysfunction is linked to debilitating psychomotor disorders, including Parkinson’s disease, Huntington’s disease, dystonia, addiction, obsessive compulsive disorder, and Tourette’s syndrome. The importance of the basal ganglia in health and disease, together with the on-going development and evolution of approaches to probe their roles and interactions, have motivated diverse research communities focused on these structures. Despite growing interest in basal ganglia research, before the inaugural Basal Ganglia Gordon Research Conference (GRC) in 2014, the only conference focused on the basal ganglia was the triennial meeting of the International Basal Ganglia Society (IBAGS), which is usually held outside the USA. Moreover, IBAGS meetings follow a typical symposium format, which contrasts markedly with the interactive, discussion-oriented format of a GRC. Since 2016, the Basal Ganglia GRC has incorporated a 1.5 day Gordon Research Seminar (GRS) organized exclusively by and for pre- and post-doctoral trainees. Beginning with the 2018 Basal Ganglia GRC & GRS, these are now regular biennial meetings. The programs for the 2020 Basal Ganglia GRC & GRS were designed by an interdisciplinary committee representing basic and clinical research in the field. A deliberate effort was made to include new speakers and topics that were not included in the 2018 meeting, with the overarching theme Basal Ganglia: From Thought to Action. Topics include cognition and decision making, cellular plasticity in the basal ganglia, interactions within and beyond basal ganglia circuits, new computational models, and clinically relevant freezing of gait. The 2020 Basal Ganglia GRC and GRS have 3 specific aims: 1) move basal ganglia research forward by featuring cutting-edge research in an interactive environment that encourages questions and discussion, challenges current thinking, identifies open questions, and provides opportunities new collaborations; 2) model diversity in basal ganglia research with respect to scientific approach and topics, gender balance, career stage, and minority representation; and 3) provide opportunities for leadership, education, and mentoring for early career scientists. Successful completion of these aims will advance basal ganglia research by encouraging new ideas and collaborations, highlighting diversity in the field, and inspiring the next generation of scientists. This should accelerate the pace of discovery and translation to the clinic, consistent with the mission of NIH.