Summer Endocrine Research Training Program

 描述(由申请人提供)：这是由NIDDK资助了10年的T35夏季内分泌研究医学生培训项目的竞争性续签申请。两个具体目标是1)在结构化的指导环境中为医学生提供基础和临床内分泌研究方面的实践培训。2)提供互动的教育体验，向医学生介绍基础、翻译和临床内分泌研究所需的基本技能。该计划每年夏天支持6-7年级医学生进行内分泌研究主题的培训，包括糖尿病-特别关注糖尿病肾脏疾病、内分泌恶性肿瘤、脑垂体对多肽激素表达的调节、大脑中的LHR、非酒精性脂肪性肝病以及代谢的激素调节。学员是从路易斯维尔大学医学院(SOM)申请夏季研究学者计划(SRSP)的一年级学生中挑选出来的。在招收少数民族和弱势群体学生方面取得了成功。学生审阅由22名教师研究导师提交的可用项目，并输入他们的第一至第三个选择，以便将受训者与导师配对。实习生和导师之间的面对面会面确保了春季学期中期的“契合度”。在为期10周的暑期培训期间，学生将与导师一起在临床或实验室环境中进行研究项目，完成负责任的研究行为培训，包括管理科学数据、伪造和伪造数据、剽窃、出版实践和负责任的作者、指导、管理和利益冲突。与人类受试者一起工作的受训者完成人类受试者和IRB培训。在研究中使用脊椎动物的受训者完成动物培训课程，并成功通过测试获得认证。所有学员都会参加每周一次的“内分泌研讨会”，该研讨会旨在介绍由T35计划的导师领导的内分泌学临床/转化性研究，最终每个学员都会向同行和导师介绍他/她的研究项目。受训者还在为期一周的SOM范围内的研究庆祝活动上与同行一起张贴海报展示他们的研究结果，其中包括国家公认的内科科学家作为主旨演讲者。海报大赛的获胜者有机会参加明年春天的全国学生研究论坛。学员可以选择继续研究，作为区别研究(DIR)跟踪丰富计划的一部分，该计划在整个医学院课程中提供研究经验，包括第三和第四年，以培养临床医生-研究人员为目标。受训者已经在同行评议的期刊上发表了他们的研究成果，受训者的结果正在被跟踪，以评估这个T35项目对内科科学家职业生涯的影响。

 DESCRIPTION (provided by applicant): This is a competing renewal application for a T35 summer medical student training program in endocrine research that has been funded by NIDDK for 10 years. The 2 Specific Aims are 1) To provide hands-on training in basic and clinical Endocrine-based research to medical students in a structured mentored environment. 2) To provide an interactive, educational experience that introduces medical students the fundamental skills necessary for basic, translational, and clinical Endocrine-based research. The program has supported the training of 6-7 second year medical students each summer in endocrine research topics including diabetes - with a particular focus on diabetic kidney disease, endocrine malignancies, pituitary regulation of peptide hormone expression, LHR in brain, non-alcoholic fatty liver disease, and hormonal regulation of metabolism. Trainees are selected from the first year class at University of Louisville School of Medicine (SOM) applying for the summer research scholar program (SRSP). A successful effort has been made to recruit students from ethnic minorities and disadvantaged backgrounds. Students review the available projects submitted by 22 faculty research mentors and enter their 1st-3rd choices, allowing matching of trainees with mentors. In-person meetings between trainees and mentors assures the 'fit' in the middle of the Spring semester. During the 10 week summer training, students work with mentors on research projects in clinical or laboratory settings, complete training in the Responsible Conduct of Research, including managing scientific data, fabrication and falsification of data, plagiarism, publication practices and responsible authorship, mentorship, stewardship, and conflict of interest. Trainees working with human subjects complete human subject and IRB training. Trainees who use vertebrate animals in their research complete animal training courses and successfully pass tests to be certified. All trainees attend a weekly "Endocrine Seminar" designed to introduce clinical/translational research in endocrinology as led by mentors in this T35 program which culminates with each trainee presenting his/her research project to peers and mentors. Trainees also present the results of their research as posters with peers at a SOM-wide, week-long celebration of research that includes nationally recognized physician scientists as keynote speakers. Winners from the poster contest have the opportunity to attend the National Student Research Forum the following Spring. Trainees may choose to continue research as part of the Distinction in Research (DIR) track enrichment program that provides research experiences throughout the medical school curriculum, including in the third and fourth years, toward the goal of developing clinician-researchers. Trainees have published their research in peer-reviewed journals and outcomes of trainees are being tracked to assess the impact of this T35 program on careers as physician- scientists.