Core E: Imaging Core

核心E：成像项目摘要 “健康老龄化和老年痴呆症”(HASD)计划的影像核心资助项目将提供 磁共振成像(MRI)、淀粉样蛋白正电子发射断层扫描的定量成像结果 (PET)使用[11C]-匹兹堡化合物B(PIB)，使用tau PET使用[18F]-AV-1451(T807，氟他西平)以 支持关联项目和核心。定量MRI测量将包括体积MRI、定量 以及血管病理的定性评估，包括脑白质高信号(WMH)和脑 脑梗塞和微出血。淀粉样蛋白和tau PET将包括标准化的汇总统计数据 区域和体素z分数分析，以了解总体负担和随时间变化。探索性措施将 继续包括静息状态功能连接磁共振成像(RS-fcMRI)、基于扩散的频谱成像 (DBSI)用于神经炎，动脉自旋标记(ASL)用于血流，使用与兼容的协议 阿尔茨海默病神经成像计划(ADNI-3)和显性遗传性阿尔茨海默病网络 (Dian)。我们将继续探索新的MRI和PET选项，因为这些选项可用，例如替代 当与HASD项目和核心相关时，用于tau病理或突触成像的PET示踪剂。我们会 还继续通过更新的Open Access版本促进HASD成像数据的共享 影像研究系列(OASIS)项目。

Core E: Imaging Project Summary The Imaging Core of the Program Project Grant "Healthy Aging and Senile Dementia" (HASD) will provide quantitative imaging results for magnetic resonance imaging (MRI), amyloid positron emission tomography (PET) using [11C]-Pittsburgh Compound B (PiB), and tau PET using [18F]-AV-1451 (T807, flortaucipir) to support the affiliated Projects and Cores. Quantitative MRI measures will include volumetric MRI, quantitative and qualitative evaluations of vascular pathology including white matter hyperintensitites (WMH) and cerebral infarctions and microhemorrhages. Amyloid and tau PET will include summary statistics for standardized regions and voxelwise z-score analyses for overall burden and change over time. Exploratory measures will continue to include resting state functional connectivity MRI (rs-fcMRI), diffusion basis spectrum imaging (DBSI) for neuroinflammation, and arterial spin labelling (ASL) for blood flow using protocols compatible with the Alzheimer Disease Neuroimaging Initiative (ADNI-3) and the Dominantly Inherited Alzheimer Network (DIAN). We will continue to explore new MRI and PET options as these become available, such as alternative PET tracers for tau pathology or synaptic imaging, when relevant to the HASD Projects and Cores. We will also continue to promote sharing of the HASD imaging data through updated releases of the Open Access Series of Imaging Studies (OASIS) project.