Data Management and Statistical Core

马萨诸塞州阿尔茨海默病研究中心：数据核心 马萨诸塞州阿尔茨海默病研究的数据管理和统计核心（Data Core） 中心（MADRC）为MADRC提供最先进的数据管理和统计专业知识， 附属研究，用于与其他ADRC的合作以及国家AD/ADRD研究 举措数据核心是MADRC研究企业的重要组成部分，因为它有助于 科学的严谨性，法规遵从性和我们中心内核心之间的强大连接性， NACC和我们中心外的其他人。它通过优化研究来最大限度地减少研究负担 通过受试者选择、终点选择、简易和适应性设计提高效率，并提供 严格的研究设计和分析指导。数据核心提供信息学专业知识， 协助，包括数据管理、及时向NACC传输数据以及查询和报告支持 所有的MADRC核心 我们将通过正式的统计建模，为MADRC理解异质性的目标做出贡献， 通过适应纵向和生存数据的统计学习方法，使用潜在变量 在有偏抽样下，通过对组学数据的分析。我们将为MADRC的目标做出贡献， 通过开发、引进和传播创新的统计方法，加速实现治愈， 优化资源的信息学工具。核心旨在调动资源（目标1，2）来支持 AD/ADRD的临床、转化和基础研究，通过贡献统计学和信息学专业知识， 跨学科团队该核心旨在制定新的战略（目标3、4）， 研究设计和公正的分析方法，并实施创新的信息资源。核心 旨在通过与研究教育组成部分（REC）合作， 定量方法的临床和转化研究人员，并吸引定量科学家到AD/ADRD research. 数据核心提供了科学严谨性的指导：它帮助MADRC研究人员进行研究设计， 确保对所有MADRC核心的研究进行有效和准确的分析。数据核心还建议MADRC 数据质量、版本控制和跟踪措施方面的研究人员。它确保所有系统的安全， 在合作伙伴IT基础架构中。核心通过传播信息，促进开放和可复制的科学 科学家们还将通过数据和软件共享，向科学界提供方法创新。

Massachusetts Alzheimer’s Disease Research Center: Data Core The Data Management and Statistics Core (Data Core) of the Massachusetts Alzheimer’s Disease Research Center (MADRC) provides state-of-the-art data management and statistical expertise for the MADRC and affiliated research studies, for collaborative efforts with other ADRCs, and for national AD/ADRD research initiatives. The Data Core is an essential component of the MADRC research enterprise as it facilitates scientific rigor, regulatory-compliance and strong connectedness across cores within our Center, and with NACC and others outside our Center. It serves to minimize the burdens of research by optimizing study efficiencies through subject selection, endpoint selection, facile and adaptive designs, as well as provides guidance on rigorous study design and analyses. The Data Core provides informatics expertise and assistance, including data-management, timely data transmission to NACC, and query and reporting support to all the MADRC Cores. We will contribute to MADRC’s goal of understanding heterogeneity through formal statistical modeling and use of latent variables, through statistical learning approaches that accommodate longitudinal and survival data under biased sampling and through analysis of omics data. We will contribute to MADRC’s goal of accelerating toward a cure by developing, importing and disseminating innovative statistical methods and informatics tools that will optimize resources. The Core aims to marshal resources (Aims 1,2) to support clinical, translational, and basic research in AD/ADRD by contributing statistical and informatics expertise to interdisciplinary teams. The Core aims to develop new strategies (Aims 3,4) to provide practical and efficient study designs and unbiased analytic methods, and to implement innovative informatics resources. The Core aims to build the future (Aims 5,6) by collaborating with the Research Education Component (REC) to train clinical and translational researchers in quantitative methods and to attract quantitative scientists to AD/ADRD research. The Data Core provides guidance on scientific rigor: it assists MADRC researchers with study design and ensures valid and accurate analyses of studies across all MADRC Cores. The Data Core also advises MADRC researchers on data quality, version control and tracking measures. It ensures all systems are secure and within the Partners IT Infrastructure. The Core promotes open and reproducible science by disseminating methodological innovations to the scientific community and through data and software sharing.