2019 Scientific Annual Meeting for CLIC and CLIC+

项目摘要-摘要 儿童白血病国际联合会(CLIC)成立于2007年，是一个由 国际研究人员，他们研究环境、遗传、感染和临床风险因素在 通过病例对照、以家庭为基础和登记联系的数据共享儿童白血病的病因学 学习。在过去的三年里，CLIC的调查人员已经开始将这些合作扩展到其他儿童 癌症；一项名为CLIC+的努力。CLIC/CLIC+现已收录全球50项儿童癌症病例对照研究 来自19个国家(39个PI)，代表大约43,000个白血病、14,000个CBT和18,000个胚胎 肿瘤病例组和对照组390万例。大多数研究都有全面的流行病学数据，约有一半 有生物制品。 虽然CLIC/CLIC+成员全年都参加电话会议，但年度面对面会议 对于计划和评估协作研究项目的进展，以及讨论 新的研究方向。2019年CLIC年会将提供一个继续讨论和 增加会员的知识库。它还将实现以下目标： ·规划和开展关于环境和遗传风险因素的汇集和验证研究(包括 GxE相互作用)，用于儿童白血病、脑肿瘤和胚胎肿瘤。 ·提出并讨论继续扩大CLIC+Intitive以包括其他儿童癌症的计划， 尤其是脑瘤，它将利用我们现有的基础设施，大学关系， 和知识；评估当前的文献，以确定CLIC最能做出贡献的研究中的差距。 ·确定和解决方法学挑战，例如，可能的选择和回忆偏见的影响； 应用统计学方法对GWA数据进行因果推断、荟萃分析。 ·与领先的国家卫生机构合作，确定对代表性不足儿童的潜在研究 癌症患者；继续鼓励参与并增加代表不足的成员 来自中南美洲和亚洲的人口。 ·为初级调查人员提供卓越的专业发展途径，以最大限度地提高他们的 成功的潜力。 ·讨论并确定最适合定量研究翻译、研究的研究领域 向利益相关者传播和沟通。

PROJECT SUMMARY – ABSTRACT The Childhood Leukemia International Consortium (CLIC), established in 2007, is a group of independent, international researchers who study the role of environmental, genetic, infectious, and clinical risk factors in the etiology of childhood leukemia through the sharing of data from case-control, family-based, and registry linkage studies. Over the past 3 years, CLIC investigators have begun to expand these collaborations to other childhood cancer; an effort dubbed CLIC+. CLIC/CLIC+ now includes 50 childhood cancer case-control studies worldwide from 19 countries (39 PIs) representing approximately 43,000 leukemia, 14,000 CBT, and 18,000 embryonal tumor cases and 3.9M controls. Most of the studies have comprehensive epidemiologic data, and about half have biospecimens. Though CLIC/CLIC+ members participate in teleconferences throughout the year, the annual in-person meeting for members is essential for planning and evaluating progress on collaborative research projects, and discussing new research directions. The 2019 CLIC annual meeting will provide a forum for continuing discussions and increasing the knowledge base of members. It will also achieve the following goals: · Plan and conduct pooled and validation studies on the environmental and genetic risk factors (including GxE interactions) for childhood leukemia, brain tumors, and embryonal tumors. · Present and discuss plans for continued expansion of CLIC+ intiative to include other childhood cancers, especially brain tumors, which will take advantage of our existing infrastructure, collegial relationships, and knowledge; evaluate current literature to identify gaps in research where CLIC can best contribute. · Identify and address methodological challenges, e.g., the impact of possible selection and recall bias, application of statistical methods for causal inference, meta-analysis of GWA data. · Partner with leading national institutes of health to identify potential studies of under-represented children with cancers; continue to encourage participation and increase membership of under-represented populations from Central and South America and Asia. · Provide an avenue for exceptional professional development to junior investigators to maximize their potential for success. · Discuss and identify research areas most suitable for quantitative research translation, research dissemination and communication to stakeholders.