Next Generation Development of Broadly Neutralizing HIV Antibodies for Prevention

HIV广谱中和抗体(BNAbs)目前正在进行艾滋病毒治疗和预防适应症的临床试验，包括目前AMP临床试验HVTN 704/HPTN 085中的VRC01，一种CD4结合部位的单抗(BnMAb)。目前的研究表明，成功的治疗和预防方案可能需要两个或更多针对不同表位的bNAb。PGDM1400和PGT121是两种识别HIV包膜蛋白上独特表位的bNAbs，可作为VRC01的补充用于覆盖。临床试验目前正在评估这些抗体；然而，目前这些抗体的临床试验材料没有半衰期延长突变，这将大大改善它们的半衰期，并缓解目前ART和预防措施中常见的依从性问题。

HIV broadly neutralizing antibodies (bnAbs) are currently being evaluated in clinical trials for both HIV treatment and prevention indications - including VRC01, a CD4-binding site monoclonal antibody (bnMAb), in the current AMP clinical trial HVTN 704/HPTN 085. Current studies indicate that 2 or more bnAbs targeting different epitopes will probably be needed for successful treatment and prevention regimens. PGDM1400 and PGT121 are two bnAbs that recognize unique epitopes on the HIV envelope protein and could be used in addition to VRC01 for coverage. Clinical trials are currently evaluating these antibodies; however, the current clinical trial material for these antibodies do not have half-life extension mutations that would greatly improve their half-life and mitigate adherence issues commonly seen with current ART and preventative measures.