Towards Multisystem-Brain Successful Aging in Schizophrenia Spectrum

项目摘要 大脑成像研究显示，与年龄相关的白色物质、神经化学物质， 精神分裂症谱系障碍患者的皮质改变。然而，成像研究通常 没有对风险因素进行系统层面的调查。精神分裂症谱系患者 疾病的寿命也短得多，发病率和死亡率高。然而，医疗并发症 研究通常不包括基于大脑的调查。目前尚不清楚为什么精神分裂症 疾病具有与年龄相关的高医疗负担。累积的压力效应是成功老化的预测， 健康的老年人。在精神分裂症谱系障碍患者中，累积的压力可能会破坏大脑 结构和功能，和/或受损的大脑结构和功能可能会扭曲对压力的正常反应 导致增加的累积应力效应。这项研究将研究累积的压力和大脑 在45岁的年龄跨度成像年龄进展，使用纵向和年龄队列交叉组合， 分段设计该研究建议跟踪与压力相关的风险因素在外围的进展， 以及大脑中与年龄相关的变化，并确定它们是否会独立或相互作用， 有助于精神分裂症患者年龄相关的医疗健康和功能结局 紊乱这些发现可以指导临床上可行的策略的发展，以拦截异常的 并促进这种毁灭性疾病患者的成功衰老。

Project Summary Brain imaging research has revealed accelerated age-related white matter, neurochemical and perhaps cortical changes in patients with schizophrenia spectrum disorders. However, imaging studies are typically brain-focused without system-level investigations on the risk factors. Patients with schizophrenia spectrum disorders also have a much shorter lifespan and high morbidity and mortality. However, medical comorbidity studies typically do not include brain-based investigations. It remains unclear why schizophrenia spectrum disorders have high age-related medical burden. Cumulative stress effects are predictive of successful aging in healthy older adults. In patients with schizophrenia spectrum disorders, cumulative stress may disrupt brain structure and function, and/or impaired brain structure and function may distort normal responses to stress leading to increased cumulative stress effects. The proposal research will study cumulative stress and brain imaging age-progression in an age span of 45 years, using a combined longitudinal and age-cohort cross- sectional design. The study proposes to track the progression of stress-related risk factors in the periphery, and the age-related changes in the brain, and to determine whether they will independently or interactively contribute to age-related medical health and functional outcomes in patients with schizophrenia spectrum disorders. These findings may guide the development of clinically actionable strategies to intercept abnormal aging and promote successful aging in patients with this devastating illness.