Einstein-Rockefeller-CUNY Center for AIDS Research

项目摘要 随着艾滋病研究界和地方、国家和全球公共卫生系统集中努力， 在预防艾滋病毒传播和结束这一流行病方面，至关重要的是要整合我们各机构的努力， 和学科，在许多研究人员之间共享资源，以实现最大的科学收益， 认识在艾滋病毒感染中心纽约目前没有艾滋病毒预防和治疗中心的情况下， 规划过程表明，将实现以纽约市为基地的CFAR的最大贡献 通过接触其他机构。因此，Einstein/Rockefeller/CUNY（ERC）-CFAR创造了一个高度 非重叠互补资源的协同新伙伴关系，将强大的基础和临床 研究机构（爱因斯坦）`有一个庞大的病人基础，全球卓越的基础科学机构 （洛克菲勒）和一个强大的公共卫生/实施科学机构（纽约市立大学），以促进研究， 预防艾滋病并结束这一流行病。我们的结构是跨学科广泛合作， 机构推动跨机构，跨学科和协调的研究议程，由ERC-CFAR 调查人员专注于“从板凳到床边到社区，再回到板凳”的研究， 通过评估在临床上有效的策略和治疗的实施， 和长凳研究ERC-CFAR将促进，协调和支持一个综合的多学科 我们的研究议程，以实现我们的使命，遏制艾滋病的流行，通过改善利用目前的 治疗和开发新的疗法，如有效的广泛中和抗体，用于预防， 减少新感染的发生率;治疗，改善受感染者的治疗结果; 和根除艾滋病毒储存库。ERC-CFAR将开展新的研究，旨在结束这一流行病， 实现五个具体目标：1）赋予积极主动、包容和综合的项目领导权 ERC-CFAR推动跨机构，跨学科和协调研究议程的方法 研究人员专注于“从实验室到床边到社区，再回到实验室”的研究，以减少艾滋病毒 发病率、改善获得治疗的机会、促进坚持治疗、改善结果和根除艾滋病毒宿主 遏制艾滋病流行; 2）利用三大科学核心支持和推进基础，临床， ERC-CFAR研究者的行为、流行病学、转化和实施研究; 3） 提供智力，技术和财政支持，以促进下一代年轻人的职业生涯， 创新和跨学科的艾滋病毒/艾滋病调查员，同时征聘常设调查员， 艾滋病毒/艾滋病研究和建立跨机构的新合作; 4）建立一个创新的社区 与政府、社区和学术界的代表建立伙伴关系， 研究，以优化艾滋病毒的诊断，治疗和预防结果。5)确定具有开创性的科学 与艾滋病研究办公室（OAR）跨NIH艾滋病毒战略计划确定的举措保持一致， 相关研究，并通过组建跨学科研究/社区ERC-CFAR团队来推动它们， 在当地与纽约市其他艾滋病毒调查人员以及在全国与其他CFAR进行创造性合作。

PROJECT SUMMARY As the AIDS research community and public health systems locally, nationally and globally focus efforts on preventing HIV transmission and ending the epidemic, it is critical to integrate our efforts across institutions and disciplines, sharing resources among many researchers to achieve the greatest gain in scientific understanding. In the current absence of a CFAR in New York, an epicenter of HIV infection, our strategic planning process made clear that the greatest contribution of a New York City-based CFAR would be achieved by reaching out to other institutions. Thus, the Einstein/Rockefeller/CUNY (ERC)-CFAR has created a highly synergistic new partnership of non-overlapping complementary resources, linking a strong basic and clinical research institution (Einstein)`with a large patient base, a globally pre-eminent basic science institution (Rockefeller), and a strong public health/implementation science institution (CUNY) to catalyze research to prevent HIV and end the epidemic. We are structured to collaborate extensively across disciplines and institutions to drive a trans-institutional, interdisciplinary, and coordinated research agenda by ERC-CFAR investigators focused on “bench to bedside to community and back to the bench” research, and translating science into reality by assessing implementation of strategies and treatments shown to be efficacious in clinical and bench research. The ERC-CFAR will stimulate, coordinate, and support an integrated multidisciplinary research agenda to achieve our mission, to arrest the AIDS epidemic, through improving utilization of current treatments and developing new therapies, such as potent broadly neutralizing antibodies, for prevention, reducing the incidence of new infections; treatment, improving treatment outcomes among infected individuals; and eradication of HIV reservoirs. The ERC-CFAR will develop new research aimed at ending the epidemic by implementing five Specific Aims: 1) To empower a proactive, inclusive, and integrated program leadership approach to drive a trans-institutional, interdisciplinary, and coordinated research agenda by ERC-CFAR investigators focused on “bench to bedside to community and back to the bench” research to reduce HIV incidence, improve access to treatment, promote adherence, improve outcomes and eradicate HIV reservoirs to arrest the AIDS epidemic; 2) To utilize three Scientific Cores to support and advance the basic, clinical, behavioral, epidemiological, translational, and implementation research of the ERC-CFAR investigators; 3) To provide the intellectual, technical, and financial support to advance the careers of the next generation of young, innovative, and interdisciplinary HIV/AIDS investigators, while recruiting established investigators into HIV/AIDS research and forging new collaborations across institutions; 4) To build an innovative community partnership with representatives from government, community, and academia, to participate in collaborative studies to optimize HIV diagnosis, treatment, and prevention outcomes. 5) Identify pioneering scientific initiatives aligned with those identified by the Office of AIDS Research (OAR) Trans-NIH Strategic Plan for HIV- related research and actuate them by assembling interdisciplinary research/community ERC-CFAR teams and creative collaborations locally with other NYC HIV investigators and nationally with other CFARs.