ERC Einstein-Rockefeller-CUNY Center for AIDS research

项目摘要 ERC-CFAR：总体 随着艾滋病毒研究界和公共卫生系统实现结束艾滋病毒流行的愿景， (EHE)艾滋病研究中心（CFAR）发挥着至关重要的作用， 为实现这一目标需要进行研究。我们成功地填补了纽约市的真空， 艾滋病毒感染的中心以前缺乏CFAR，通过创建爱因斯坦-洛克菲勒-纽约市立大学CFAR（ERC- CFAR）。《紧急救济协调员-CFAR》汇集并协同发挥了以下方面的互补专长和资源： 来自一个强大的基础和临床研究机构的研究人员与一个治疗超过6，200人的卫生系统相联系 阿尔伯特·爱因斯坦医学院（Albert Einstein College of Medicine，Einstein）是一所全球领先的基础科学学院， 洛克菲勒大学（洛克菲勒）;以及一个强大的公共卫生/实施科学机构， 纽约市立大学公共卫生学院/亨特学院（CUNY），同时与纽约市卫生部建立联系， 健康和心理卫生。我们的愿景是让ERC-CFAR成为创造创新的催化剂， 有助于EHE打破机构和学科筒仓在我们的互补基础，翻译， 临床、流行病学、行为和实施研究计划，以加速新技术的开发 治疗，评估和克服可接受性，吸收和坚持的障碍，并预防和治愈艾滋病毒 感染. ERC-CFAR核心、SWG和基础设施在扩大研究方面的成功 我们的OAR FRB从2015财年的约3400万美元增加了30%以上，这说明了我们三个机构的生产力 在2020财年达到约4460万美元，ERC-CFAR调查人员发表了超过1,250篇论文。我们的ESI获得 约2000万美元的外部赠款资金，包括约750万美元的NIH赠款，我们授予了约50万美元的催化剂 14项试点赠款的投资回报率超过16倍。我们还整合了社区成员的关切， 包括威尔斯亲王医院，透过组织一个崭新、高度跨机构及 跨学科科学工作组（SWG），超过30名成员专注于我们社区的 优先研究领域，艾滋病毒和心理健康。在这次更新中，我们建议在我们取得的成就的基础上， 进一步促进研究，通过这些具体目标结束流行病：1）聚集跨机构， 跨学科，社区包容的ERC-CFAR研究团队，以制定和实施新的战略， 减少艾滋病毒传播，改善预防和治疗，促进持续的病毒抑制， HIV病毒库; 2）通过我们生物标志物的尖端服务增加我们研究的影响力 和先进技术核心，行为和实施科学核心，临床和转化 科学核心; 3）为了指导下一代艾滋病毒研究人员，招募已建立的非艾滋病毒研究人员 进入艾滋病毒研究，并在爱因斯坦，洛克菲勒和纽约市立大学，其他NIH资助的 中心，区域学术中心，我们的公共卫生部门和社区合作伙伴，以支持一个 通过发展核心和当前的艾滋病毒和心理健康以及未来的工作组创新EHE议程。

PROJECT SUMMARY ERC-CFAR: OVERALL As the HIV research community and public health systems implement the vision of Ending the HIV Epidemic (EHE), Centers for AIDS Research (CFAR) play a crucial role leading the trans-institutional and interdisciplinary research efforts needed to achieve this goal. We successfully filled a vacuum in New York City, a continuing epicenter of HIV infection previously lacking a CFAR, by creating the Einstein-Rockefeller-CUNY CFAR (ERC- CFAR). The ERC-CFAR brings together and synergizes the complementary expertise and resources of researchers from a strong basic and clinical research institution linked to a health system which treats >6,200 people with HIV, the Albert Einstein College of Medicine (Einstein); a globally pre-eminent basic science institution, Rockefeller University (Rockefeller); and a strong public health/implementation science institution, CUNY School of Public Health/Hunter College (CUNY), while establishing linkages to the NYC Department of Health and Mental Hygiene. Our vision is for the ERC-CFAR to serve as a catalyst to create innovation and contribute to EHE by breaking down institutional and disciplinary silos in our complementary basic, translational, clinical, epidemiologic, behavioral, and implementation research programs to accelerate development of new therapies, assess and overcome barriers to acceptability, uptake, and adherence, and prevent and cure HIV infections. The success of the ERC-CFAR Cores, SWGs, and infrastructure in amplifying the research productivity of our three institutions is illustrated by a >30% increase in our OAR FRB from ~$34 million in FY15 to ~$44.6 million in FY20 and the publication of >1,250 papers by ERC-CFAR investigators. Our ESIs obtained ~$20 million of external grant funding, including ~$7.5 million in NIH grants catalyzed by ~$500K we awarded for 14 pilot grants, a >16-fold return on investment. We also integrated the concerns of our community members, including PWH, into our strategic planning process by organizing a novel, highly trans-institutional and interdisciplinary Scientific Working Group (SWG), with greater than 30 members focused on our community’s priority research area, HIV and Mental Health. In this renewal, we propose to build on our accomplishments to further catalyze research to end the epidemic through these Specific Aims: 1) To assemble transinstitutional, interdisciplinary, community-inclusive ERC-CFAR research teams to develop and implement new strategies to reduce HIV transmission, improve prevention and treatment, promote sustained viral suppression, and eradicate HIV reservoirs; 2) To increase the impact of our research through the cutting-edge services of our Biomarkers and Advanced Technologies Core, Behavioral and Implementation Science Core, and Clinical and Translational Science Core; 3) To mentor the next generation of HIV investigators, recruit established non-HIV investigators into HIV research, and forge new collaborations across Einstein, Rockefeller, and CUNY, other NIH-funded centers, regional academic centers, our public health departments, and community partners to support an innovative EHE agenda through the Developmental Core and current HIV & Mental Health and future SWGs.