Applied Research Section

项目摘要 系统遗传学致力于解释遗传信息的整合、协调和表达 跨越所有尺度的表型--分子、细胞、生理和群体；以及跨越许多背景 -健康、疾病、感染、环境等。这些系统级方法在网络上运行，并具有 解释生物系统的高阶函数和涌现特性的可能性。与 -组学技术的爆炸性增长、用于大数据分析的高级计算方法以及 人类和模式生物种群的高级遗传参考序列，系统遗传学 方法比以往任何时候都更强大。我们提议的试点项目将产生这些方法， 体外系统遗传学服务平台的能力、基础设施和概念验证。这个项目 是对系统遗传学资源日益增长的兴趣的回应，系统遗传学资源是MMRRC的一个关键增长领域 财团。此外，虽然项目的范围目前仅限于CC/DO的创始人近交系 作为基因参考人群，它补充了我们实验室和整个MMRRC的其他资助努力 财团将从遗传参考实验室小鼠种群中开发资源，以支持 系统遗传学社区。

PROJECT ABSTRACT Systems genetics endeavors to explain the integration, coordination, and expression of genetic information across phenotypes at all scales - molecular, cellular, physiological, and population; and across many contexts – health, disease, infection, environment, etc. These systems-level approaches operate on networks and have the potential to explain higher-order functions and emergent properties of biological systems. With the explosion of -omics technologies, advanced computational methods for big data analysis, and the availability of advanced genetic reference sequences for human and model organism populations, systems genetics approaches are more powerful than ever. Our proposed pilot project will generate the methodologies, capabilities, infrastructure, and proof-of-concept for an in vitro systems genetics service platform. This project is responsive to the rising interest in systems genetics resources, a key growth area for the MMRRC consortium. Moreover, while the scope of project is currently limited to the founder inbred strains of the CC/DO genetic reference populations, it complements other funded efforts in our laboratories and across the MMRRC consortium to develop resources from genetic reference laboratory mouse populations to support the growth of the systems genetics community.