Maternal immune activation and adolescent exposure to cannabis in rodents: Do two developmental “hits” lead to schizophrenia-like changes in brain and behaviour?

精神分裂症的原因很可能是由于遗传或不利环境导致的早期大脑发育。我们将在一个老鼠模型中检查两个连续的环境“击中”：怀孕期间感染，然后是青少年早期使用大麻。我们将跟踪青春期后期和年轻人大脑的变化。我们还将评估成年后的行为和大脑功能，看看这些动物是否表现出与我们在精神分裂症中看到的相似的模式。

The cause of schizophrenia most likely lies in early brain development due to either genetics or adverse environments. We will examine two successive environmental ‘hits’ in a rat model: infection during pregnancy followed by early adolescent cannabis use. We will track changes in the brain that occur in late adolescence and in young adults. We will also assess behaviour and brain function in adulthood to see if the animals exhibit patterns that mimic those that we see in schizophrenia.