Pathogenesis and therapeutic targeting of immune disorders

项目总结/摘要 失调的免疫应答对于广泛的免疫缺陷病毒的发病机制和表达至关重要。 造成巨大发病率和死亡率负担的一系列疾病。培训的总体目标 一笔赠款将为3名博士预科生提供培训，他们的研究将揭示致病机制 免疫介导的疾病和促进变革性的治疗方法，符合使命 国家卫生研究院候选人将从免疫学研究生课程（ImmGP）和医学 辛辛那提儿童医院医疗中心（CCHMC）和宾夕法尼亚大学的科学家培训计划 辛辛那提医学院。位于CCHMC内，这是一项首屈一指的儿科研究， 由于申请人来自美国的高等院校，因此，申请人数目众多，而且种类繁多。入境计划学生可获 在免疫学、研究伦理学、拨款写作和生物统计学方面的示范性教学。培训 该计划将由一名主任和联合主任（博士希尔德曼和辛格）谁，沿着34优秀 培训学院（TF），在指导博士前学生方面有丰富的经验。学生将与一个 来自CCHMC/UCCOM多个部门的不同TF组（包括MD、MD/PhD和PhD）， 他们共同关注人类疾病免疫学基础的机制理解。 学生在这个培训计划将沉浸在一个独特的环境：TF有资金充足的研究 从基础免疫学到疾病的动物模型再到人类患者的临床试验 提供了巨大的机构资源（例如，支持研究生教育和教师研究，削减- 边缘核心设施，独特的患者队列）;一个合作研究学生交流计划， 德国大学和研究所为国际研究提供了独特的机会， 免疫学该计划的毕业生将独特地准备将免疫学的创新从 实验室工作台到床边，并将独立的研究生涯做好准备。

Project Summary/Abstract Dysregulated immune responses are of central importance to the pathogenesis and expression of a wide spectrum of diseases that cause an immense burden of morbidity and mortality. The overall Aim of the training grant is to provide training for 3 pre-doctoral candidates, whose research will uncover pathogenic mechanisms of immune-mediated disease and facilitate transformative therapeutic approaches, consistent with the mission of the NIH. Candidates will be recruited from the Immunology Graduate Program (ImmGP) and the Medical Scientist Training Program at Cincinnati Children’s Hospital Medical Center (CCHMC) and the University of Cincinnati College of Medicine (UCCOM). Housed within CCHMC, one of the premiere pediatric research institutions in the US, the ImmGP attracts a strong and diverse pool of applicants. ImmGP students receive exemplary didactic instruction in immunology, research ethics, grant writing, and biostatistics. The training program will be led by a Director and Co-Director (Drs. Hildeman and Singh) who, along with 34 outstanding Training Faculty (TF), have significant experience in mentoring pre-doctoral students. Students will work with a diverse group of TF (comprised of MDs, MD/PhDs, and PhDs), from multiple departments at CCHMC/UCCOM, who share a collective focus on the mechanistic understanding of the immunologic basis of human disease. Students in this training program will be immersed in a distinctive environment: TF have well-funded research programs that span basic immunology to animal models of disease to clinical trials in human patients; CCHMC provides tremendous institutional resources (e.g., support for graduate education and faculty research, cutting- edge core facilities, unique patient cohorts); a collaborative research student exchange program with a German University and Research Institute provides a unique opportunity for international studies in immunology. Graduates of this program will be uniquely poised to bring innovations in immunology from the laboratory bench to the bedside and will be well-prepared for independent research careers.