Core H: Latino Core

抽象-拉丁裔核心 拉什阿尔茨海默病核心中心(拉什ADCC；P30AG10161)支持 阿尔茨海默病的病因、发病机制、诊断、治疗和预防及相关的创新研究 通过为研究人员提供一个激励的跨学科环境，以及独特和高度的 有价值的临床和尸检数据，以及生物标本。Rush ADCC有八个内核，支持 各种及时和重要的研究领域，包括从正常老龄化过渡到 MCI到AD，正常衰老和MCI的神经生物学，以及现代组学技术的使用 确定新的治疗靶点。 拉什ADCC招募了大量非痴呆症黑人和白人参加临床和 宗教教团是研究的核心。尽管拉美裔社区并不是一个主要的焦点，但相当大 到目前为止，拉丁裔社区的进步已经为拉丁裔核心奠定了基础。拉丁裔的总体目标是 CORE于2015年8月资助，旨在招募并跟踪基线上没有痴呆症的拉丁裔老年人，以及 生成数据以及死前和死后生物标本，以支持高质量、尖端 由外部资助的专注于认知全过程的研究。这些目标将通过以下方式实现 旨在加强Rush ADCC和更广泛的ADC研究界的四个具体目标： 目标1是招募和招募同意进行年度详细临床评估的无痴呆症的拉丁裔老年人 以及死前生物标本的收集。目标2是进行统一的结构化基线和 年度后续评估，包括神经学检查、神经心理学和运动 对居住在社区的拉丁裔进行性能测试，并对AD和AD事件应用统一的诊断标准 MCI，并将数据收集与宗教教团研究核心和临床核心协调起来，以促进 健康差距研究。目标3是将创新和文化定制的教育项目整合到 提高拉美裔美国人对脑和脊髓尸检重要性认识的临床评估 以便在短时间内进行高验尸率；并在 保持最大灵活性的时尚，以支持多样化的研究。目标4是增加运力 进行外部资助的研究，包括结合当代生物化学和 分子技术和临床试验，通过提供环境和资源，促进纳入 将受试者、临床数据和尸检组织纳入研究项目，并提供培训机会 初级教员。

ABSTRACT - LATINO CORE The Rush Alzheimer's Disease Core Center (Rush ADCC; P30AG10161) supports the performance of innovative research on the etiology, pathogenesis, diagnosis, treatment, and prevention of AD and related conditions, by providing researchers with a stimulating inter-disciplinary environment, and unique and highly valued clinical and post-mortem data, and biologic specimens. The Rush ADCC has eight cores that support a variety of timely and important areas of research including risk factors for the transition from normal aging to MCI to AD, the neurobiology of normal aging and MCI, and the use of contemporary omics technologies to identify novel therapeutic targets. The Rush ADCC has enrolled large numbers of Blacks and Whites without dementia into the Clinical and Religious Orders Study Cores. Although the Latino community has not been a major focus, considerable progress in the Latino community to date has set the stage for the Latino Core. The overall goal of the Latino Core, funded in August, 2015, is to enroll and follow older Latinos free of dementia at baseline, and generate data and ante- and post-mortem biospecimens, to support high quality, cutting edge, externally-funded studies that focus on the full spectrum of cognition. These goals will be addressed with four Specific Aims designed to enhance the Rush ADCC and the wider ADC research community: Aim 1 is to recruit and enroll older Latinos without dementia who agree to annual, detailed clinical evaluations and the collection of ante-mortem biologic specimens. Aim 2 is to conduct uniform structured baseline and annual follow-up evaluations, including neurological examinations and neuropsychological and motor performance testing, of community-dwelling Latinos, and apply uniform diagnostic criteria for incident AD and MCI, and harmonize data collection with the Religious Orders Study Core and the Clinical Core to facilitate health disparities research. Aim 3 is to integrate innovative and culturally tailored educational programs into the clinical evaluation to increase awareness of the importance of brain and spinal cord autopsy in Latinos and to facilitate a high autopsy rate with a short post-mortem interval; and harvest and preserve brain tissue in a fashion that retains maximum flexibility to support a diverse array of studies. Aim 4 is to increase the capacity to conduct externally-funded research, including studies that incorporate contemporary biochemical and molecular techniques and clinical trials, by providing an environment and resources to facilitate the inclusion of subjects, clinical data, and post-mortem tissue into research projects and to provide training opportunities for junior faculty.