Training Physician Scientists in Pediatric Oncology

总结/摘要 这是我们的T32培训补助金（T32计划）更新的修订后的竞争性申请。程序 位于儿童癌症和血液病中心（CCCBD），这是最大的 和美国顶尖的儿科肿瘤学项目。这个名为“培训医生- 儿科肿瘤科学家”由两个整合良好的培训单位组成，CCCBD位于 儿童医院洛杉矶（CHLA）校园和NCI资助的诺里斯综合癌症中心， 位于南加州大学健康科学校区（HSC）的南加州大学（USC-Norris）， CCCBD是其中的一个组成部分。该计划将为三年的密集培训提供重要支持。 跨学科实验室研究培训，每年从4-5人中选出一名医学博士学员 从20-30名申请者中被儿科接受的亚专科肿瘤学研究员 CCCBD的血液学-肿瘤学奖学金计划。最终目标是让他们为全职工作做好准备。 儿科癌症研究的学术生涯。受训者进行与儿童生物学有关的研究 在CHLA和USC-Norris的16名T32项目研究导师的实验室中， NIH资助的跟踪记录（目前NIH资助了88%）和指导成就。通过执行这些 研究项目在一个更大的互动环境中的国家癌症研究所资助的综合癌症中心 参加正式和定制的课程，包括职业发展和强有力的监督， 指导委员会，学员发展必要的知识基础，关键能力和技术技能， 成为成功的独立调查员。这个T32计划的一个重点是灌输哲学 在医生-科学家实习生和综合转化研究团队之间建立桥梁。在 为了支持这一目标，学员积极参加CCCBD的四个团队科学计划之一 （神经母细胞瘤，白血病，神经肿瘤和骨髓移植/细胞疗法）。体制 环境提供了丰富的资源和丰富的知识环境，为培训研究有关， 人类疾病和儿科肿瘤学。这包括核心培训资源，强大的师资力量， CCCBD，CHLA和USC-Norris的萨班研究所的项目，以及进入 艺术核心设施和设备。修订后的申请要求逐步增加 从第一年的一个职位到第三年的三个职位。

Summary/Abstract This is a revised competitive application for the renewal of our T32 training grant (T32 Program). The Program is located within the Children's Center for Cancer and Blood Diseases (CCCBD), which is among the largest and top-ranked pediatric oncology programs in the US. This T32 Program entitled “Training Physician- Scientists in Pediatric Oncology” is composed of two well integrated training units, the CCCBD located on the Children's Hospital Los Angeles (CHLA) campus and the NCI funded Norris Comprehensive Cancer Center of the University of Southern California (USC-Norris) located on the Health Sciences Campus (HSC) of USC and of which the CCCBD is an integral part. The Program will provide vital support for three years of intensive interdisciplinary laboratory research training for one MD trainee selected each year from among 4-5 subspecialty oncology fellows who have been accepted from a pool of 20-30 applicants into the Pediatric Hematology-Oncology Fellowship program of the CCCBD. The final goal is to prepare them for full-time academic careers in pediatric cancer research. Trainees conduct research relevant to the biology of childhood cancer in the laboratories of 16 T32 Program Research Mentors at CHLA and USC-Norris, who have a solid track record of NIH funding (88% currently NIH funded) and mentoring accomplishments. By performing these research projects within the larger interactive environment of an NCI-funded Comprehensive Cancer Center and participating in formal and customized curricula that include career development and strong oversight by mentoring committees, trainees develop the knowledge base, critical abilities and technical skills necessary to develop into successful independent investigators. A key focus of this T32 Program is to instill the philosophy of bridging interactions between physician-scientist trainees and integrated translational research teams. In support of this aim, trainees actively participate in one of four Team Science Programs of the CCCBD (Neuroblastoma, Leukemia, Neural Tumors and Bone Marrow Transplant/Cellular Therapies). The institutional environment provides abundant resources and a rich intellectual milieu for training in research relevant to human disease and pediatric oncology. This includes core training resources, the strong faculties and programs of the CCCBD, The Saban Research Institute of CHLA and USC-Norris, and access to state of the art core facilities and equipment. This revised application requests a progressive increase in the number of positions each year from one the first year to three the third year and thereafter.