The function and misfunction of serum apolipoproteins: lipid binding and protein misfolding.

蛋白质和脂类之间的相互作用是所有生物体细胞过程的一个基本方面。脂结合蛋白必须在结构上是动态的才能发挥其功能，这就使它们容易发生错误折叠和聚集。该项目旨在评估载脂蛋白与脂质结合的结构机制，以及这些蛋白如何平衡这一功能与其错误折叠的倾向。它将集中在载脂蛋白(Apo)A-I作为一种模型血清载脂蛋白，它结合脂类并介导脂质在循环中的运输。该项目还旨在对蛋白质-脂质相互作用、载脂蛋白的结构机制以及各种蛋白质的错误折叠过程提供重要的新理解。

The interaction between proteins and lipids is a fundamental aspect of cellular processes in all organisms. Lipid binding proteins must be structurally dynamic to perform their function, which predisposes them to misfolding and aggregation. This project aims to assess the structural mechanisms of lipid binding by apolipoproteins, and how these proteins balance this function with their propensity to misfold. It will focus on apolipoprotein (apo)A-I as a model serum apolipoprotein that binds lipids and mediates lipid transport in circulation. This project also aims to provide an important new understanding of protein-lipid interactions, the structural mechanisms of apolipoproteins, and the process of misfolding in a diverse range of proteins.