Methodologic Core

方法学核心的目标是支持高影响力的临床研究，重点是 肌肉骨骼疾病的诊断、治疗和预防。具体来说，方法论 核心将提供研究所需的当代数据科学基础设施， 利用电子病历（EMR），以及收集患者报告结果的试验。 我们将围绕三大活动组织：严谨新颖的研究设计;二次利用 用于研究的EMR数据;以及原始数据收集和实用的临床试验实施。在 特别是，多个EMR系统的连接正在为大规模的 临床研究，但也需要新的方法来提取可靠的信息， 设计适合患者和医疗服务特点的试验 系统.华盛顿大学生物医学统计中心（CBS）提供了 多项观察性和随机研究的信息学和统计学领导力， 在肌肉骨骼疾病，并具有独特的地位，为扩大 在NIAMS使命的广泛范围内的影响。

The goal of the Methodologic Core is to support high-impact clinical research focusing on the diagnosis, treatment, and prevention of musculoskeletal diseases. Specifically, the Methodologic Core will provide the contemporary data science infrastructure necessary for studies that leverage electronic medical records (EMR), and for trials that collect patient reported outcomes. We will organize around three major activities: rigorous and novel study designs; secondary use of EMR data for research; and primary data collection and pragmatic clinical trial conduct. In particular, the linkage of multiple EMR systems is opening new opportunities for large-scale clinical research, but also demands new methods for the extraction of reliable information, and for the design of trials that can tailor to the characteristics of patients and health care delivery systems. The University of Washington Center for Biomedical Statistics (CBS) has provided informatics and statistical leadership to multiple observational and randomized studies focusing on musculoskeletal disorders, and is uniquely positioned to provide the foundation for expanded impact within the broad scope of the NIAMS mission.