Geriatrics Research: From Bench to Bedside

项目摘要 这份名为《老年医学研究：从长凳到床边》的U13会议拨款申请是一项竞争 代表美国老年医学学会(AGS)和老年医学与临床学会提交的续签 国家老龄研究所(NIA)老年学分会。AGS/NIA“长凳到床边”系列，现已进入 它的第10个年头非常成功(见支持函和背景)。《公约》的总体目标 系列是推进对新出现的老年学主题的研究，这些主题有可能极大地改善临床护理或 对老年人的预防。在这里，我们推荐三个会议，每个会议都集中在一个常见的和临床上的 一对重要的与年龄相关的疾病。这些会议将探讨基础、临床和翻译 与减少共病和改善老年人的健康结局有关的问题。 随着人口老龄化，患有多种慢性病或多病的美国人的数量， 继续增长。尽管大多数老年人患有多发性疾病，但我们缺乏证据证明 在这一快速增长的人口群体中测试过的治疗方法和工具。我们有 对年龄相关疾病的共同生理机制的了解有限。的确有 迫切需要推进科学知识和比较有效性研究，以改善医疗保健 多发病患者的实践和健康结果。然而，多发病是一个不同的问题， 这可能会阻碍推进可操作的研究议程的努力。拟议的系列将创建一个 深化有意义的协作并确定具体知识和需求差距并确定其优先顺序的机会 通过关注精心挑选的三对条件之间的界面。建议的主题是 会议系列包括：1)感觉障碍与认知衰退，2)骨质疏松与软组织(肌肉/脂肪) 疾病，以及3)癌症和心血管疾病。具体目标是：1)办好三个多学科 将确定老龄化研究方面的知识差距和未来优先事项的会议；2)在 推动高质量研究和新协作的方式，以及3)促进多样化和 受过培训并致力于解决这些问题的高效研究队伍。的主要功能 每次会议将是：跨学科、研究所和利益相关者的网络；鼓励 来自代表性不足群体的参与；新秀职业发展计划； 确保及时传播，支持新兴协作，保持势头。我们的计划受益于 组织者的经验、先前的评估和过去十年中吸取的教训。此外，反馈 与会者在最初会议上的发言将有助于微调后续会议的计划和结构。这个 系列会议由一个监督委员会领导。每一次会议的计划委员会包括以下方面的专家 相关领域、国家臭氧机构代表和至少一名初级调查员；由规划委员会负责 用于会议的内容和交付、会后活动和传播调查结果。

Project Abstract This U13 conference grant application titled “Geriatrics Research: From Bench to Bedside” is a competing renewal submitted on behalf of the American Geriatrics Society (AGS) and the Geriatrics and Clinical Gerontology Branch of the National Institute on Aging (NIA). The AGS/NIA “Bench to Bedside” series, now in its 10th year, has been highly successful (see Letters of Support and Background). The overall objective of the series is to advance research on emerging geriatrics topics with potential to greatly improve clinical care or prevention for older adults. Here, we propose three conferences, each focused on a common and clinically important pair of age-related conditions. The conferences will probe basic, clinical, and translational questions relevant to reducing co-occurrence and improving health outcomes for seniors with each dyad. As the population ages, the number of Americans with multiple chronic conditions, or multimorbidity, continues to grow. Although the majority of seniors have multimorbidity, we lack an evidence base for treatments and tools that have been tested in this rapidly increasing segment of the population. We have limited understanding of shared physiological mechanisms that underlie or link age-related conditions. There is a pressing need to advance scientific knowledge and comparative effectiveness research that will improve care practices and health outcomes for people with multimorbidity. Yet multimorbidity is a heterogeneous issue, which can hinder efforts to advance an actionable research agenda. The proposed series will create an opportunity to deepen meaningful collaborations and identify and prioritize specific knowledge and need gaps by focusing on the interface between three carefully selected pairs of conditions. The proposed topics for the conference series are: 1) sensory impairment & cognitive decline, 2) osteoporosis & soft tissue (muscle/fat) disorders, and 3) cancer & cardiovascular disease. The Specific Aims are: 1) Hold three multidisciplinary conferences that will define knowledge gaps and future priorities in aging research, 2) Foster dialogue in a manner that advances high quality research and new collaboration, and 3) Foster the growth of a diverse and productive research workforce that is trained and committed to addressing these problems. Key features of each conference will be: networking across disciplines, institutes, and stakeholders; strategies to encourage participation from under-represented groups; a career development program for Rising Stars; mechanisms to ensure timely dissemination, support emerging collaborations, and sustain momentum. Our plans benefit from the organizers’ experience, prior evaluations, and lessons learned over the past decade. Additionally, feedback from participants at initial meetings will help fine-tune the program and structure of subsequent meetings. The conference series is led by an Oversight Board. A Planning Committee for each conference includes experts in relevant fields, NIA representation, and at least one junior investigator; the Planning Committee is responsible for content and delivery of the meeting, post-meeting activities, and dissemination of findings.