Smart template for prostate biopsy guidance

物理科学公司(PSI)与布里格姆和妇女医院放射科合作 医院(BWH)建议开发一种双作用智能模板来帮助经会阴靶向前列腺 在磁共振成像(MRI)下进行的活组织检查和随后的局部治疗程序- 指导。尽管MRI成像在识别前列腺癌方面具有很高的敏感性，但不准确的定位 将活检针插入器官的MRI突出区域通常无法确认癌症的存在和线索 反复昂贵的活组织检查和可能延误的治疗。PSI/BWH团队已经开发出一种被动的 网格智能模板技术，能够准确地将活检针插入并定位到 可疑的前列腺癌组织。它的临床疗效已经在多名患者中得到证实。这 然而，技术需要进一步的改进、先进的技术和临床评估来支持 商业化。在这个快速通道计划中，我们建议通过消除 无源栅格，支持无数的入口点，并自动定位和角度的针。这个 有角度的插入可以避免会结构，如疤痕组织和其他引起 活检针偏转。还将监测患者在活检过程中的活动情况，并 活检针轨迹将使用针对准确活检针的定制算法进行校正 移位到靶肿瘤病变。将首先评估双动作智能模板，并 在会阴动物模型中进行优化，然后将使用3T在人体患者身上测试其疗效 BWH的核磁共振扫描仪。

Physical Sciences Inc. (PSI), in collaboration with the Department of Radiology at Brigham and Women’s Hospital (BWH), proposes to develop a double-action Smart Template to aid transperineal targeted prostate biopsies and subsequent focal therapy procedures performed under magnetic resonance imaging (MRI)- guidance. Despite the high sensitivity in identifying prostate cancer with MRI imaging, inaccurate placement of the biopsy needle into the MRI highlighted area of the organ often fails to confirm cancer presence and leads to repeated costly biopsies and potentially delayed treatment. The PSI/BWH team has developed a passive grid Smart Template technology that enables accurate insertion of the biopsy needle and positioning into a suspicious prostate cancer tissue. Its clinical efficacy has already been demonstrated in multiple patients. This technology however requires further improvement, advanced engineering, and clinical evaluation to support commercialization. In this Fast-Track program we propose to further advance the technology by eliminating the passive grid, enabling countless entry points, and automated positioning and angulation of the needle. The angled insertion will enable avoidance of the perineal structures such as scar tissue and other areas that cause deflection of biopsy needle. Patient movement during the biopsy procedures will also be monitored, and the biopsy needle trajectory will be corrected using a custom algorithm for the accurate biopsy needle displacement to the target cancer lesion. The double-action Smart Template will be first evaluated and optimized in perineal animal models, and then its efficacy will be tested in vivo in human patients utilizing a 3T MRI scanner at BWH.