Bioinformatics Core

项目摘要 PDTC生物统计学和生物信息学核心是PDTC的关键集成点，并将提供 专业知识不仅可以解释与我们每个PDX模型相关的复杂“组学”数据， 还具有鉴定与药物正相关或负相关的肿瘤分子特征的专业知识 应答PDTC生物统计学和生物信息学核心的目标是： 1.为实验设计提供统计建模，特别是关于动物临床前试验 研究项目和试点项目的分析。 2.合作进行研究项目的数据分析、结果解释和最终研究报告的撰写 报告和手稿。 3.制定可在HCI实施的实验设计和分析的标准实践， #21453;，并在PDXNet？ 4.对基因组数据进行主要和次要分析， 变化，以及数据组织和分发。 5.促进HCI和PLAN之间以及整个PDXNet的数据交换。 6.最大限度地利用对人道主义协调机构和人道主义事务协调机构两个现有机构核心的现有支助， 患者源性类器官（PDO）和基于PDX的工作，包括软件和数据库开发。 !

Project Summary The PDTC Biostatistics and Bioinformatics Core is a key integration point of the PDTC, and will provide the expertise to not only interpret complex “omics” data that is already associated with each of our PDX models, but also the expertise to identify molecular features of tumors that positively or negatively correlate with drug responses. The goals of the PDTC Biostatistics and Bioinformatics Core are: 1. To provide statistical modeling for experimental design, particularly with respect to animal preclinical trials and their analyses, for both Research Projects and Pilot Projects. 2. To collaborate in research projects’ data analysis, interpretation of results, and the writing of final study reports and manuscripts. 3. To develop standard practices for experimental design and analytics that can be implemented at HCI and BCM, and across the PDXNet. 4. Perform primary and secondary analysis of genomic data, identification of statistically significant changes, and data organization and distribution. 5. To facilitate data exchange between HCI and BCM, and across the PDXNet. 6. To maximize use of existing support for the two existing institutional cores at HCI and BCM in support of patient-derive organoid (PDO) and PDX-based work, including software and database development. !