Biostatistics Core

生物统计学核心

• 批准号: 7786723
• 负责人: Kenneth Michael Boucher
• 金额: $ 7.84万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-12 至 2015-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7786723
• 关键词: Address; Age; Algorithms; American; Biostatistics Core; Cancer Etiology; Cessation of life; Clinical; Clinical Research; Collaborations; Colon; Colon Carcinoma; Colonic Adenoma; Colorectal Cancer; Complex; Data; Data Analyses; Data Quality; Development; Ensure; Experimental Designs; Family history of; Functional disorder; Goals; Laboratories; Laboratory Animals; Manuscripts; Measures; Monitor; Mutation; Participant; Polyps; Preventive; Preventive screening; Program Research Project Grants; Registries; Reporting; Research; Research Design; Research Personnel; Research Project Grants; Risk; Risk Factors; Sample Size; Second Primary Cancers; Services; Statistical Methods; United States; Universities; Utah; Work; Writing; adenoma; age group; cancer diagnosis; design; high risk; member; programs; research study; statistics; tool

Colorectal cancer is the third most commonly diagnosed cancer and the second leading cause of cancer-related deaths in the United States and the developed world. Despite the availability of proven effective preventive screening tools, less than 50% of average risk Americans in the high-risk age group (over 50) have been screened. After age, personal and family history of colon and/or polyps is the most common risk factor. Following APC mutation, the mechanisms of adenoma formation and progression are proving complex. The integrated approach of the 4 projects addresses these issues from several different perspectives. The Biostatistics Core (Core D) provides statistical expertise for all University of Utah Colon Cancer PPG projects, cores, investigators and participants. Core members collaborate in 1) the design, implementation, and analysis of laboratory and clinical research studies, and 2) the development and application of new statistical methods and analysis algorithms to address problems relevant to PPG projects. Core staff will function as collaborative members of research teams to jointly develop design and analysis plans to address research questions. Functions provided by the Biostatistics Core include development of experimental designs, participation in study implementation, data quality monitoring, statistical analysis and interpretation of findings, and collaboration on presentation of results. To achieve these functions, the Core director and biostatisticians collaborate with project investigators, and are in regular contact with the project and core leaders. The primary objectives of the Biostatistics Core are 1) To provide study design and review of all laboratory, animal and clinical studies including feasibility assessment, power analysis and sample size calculation. 2) To collaborate in projects' data analysis, interpretation of results, and the writing of final study reports and manuscripts. 3) To work with the Analytical Core (Core B) and Clinical Core (Core C) in their activities to ensure data quality and timely data capture. 4) To develop and evaluate statistical methods for experimental design and data analysis as required for PPG projects. The Biostatistics Core supports all four Colon Cancer PPG projects at the University of Utah.

结直肠癌是第三大最常见的诊断癌症，也是美国和发达国家癌症相关死亡的第二大原因。尽管有有效的预防性筛查工具，但在高风险年龄组（50岁以上）的平均风险美国人中，只有不到50%的人接受了筛查。除年龄外，结肠和/或息肉的个人和家族史是最常见的风险因素。APC突变后，腺瘤形成和进展的机制被证明是复杂的。4个项目的综合办法从几个不同的角度解决了这些问题。生物统计学核心（核心D）为所有犹他州结肠癌PPG项目、核心、研究者和参与者提供统计专业知识。核心成员在1）实验室和临床研究的设计，实施和分析，以及2）新的统计方法和分析算法的开发和应用，以解决与PPG项目相关的问题。核心工作人员将作为研究小组的协作成员，共同制定设计和分析计划，以解决研究问题。生物统计学核心提供的功能包括开发实验设计，参与研究实施，数据质量监测，统计分析和结果解释，以及结果展示方面的合作。为了实现这些功能，核心主任和生物统计学家与项目调查员合作，并与项目和核心领导人定期联系。生物统计学核心的主要目标是1）提供研究设计和所有实验室，动物和临床研究的审查，包括可行性评估，功效分析和样本量 计算. 2)协助项目的数据分析、结果解释、最终研究报告和论文的撰写。3)与分析核心（核心B）和临床核心（核心C）在其活动中合作，以确保数据质量和及时的数据采集。4)开发和评估PPG项目所需的实验设计和数据分析的统计方法。 生物统计学核心支持犹他州大学的所有四个结肠癌PPG项目。