Biostatistics Core

结直肠癌是美国和发达国家第三大最常诊断的癌症，也是导致癌症相关死亡的第二大原因。尽管有已证实有效的预防性筛查工具，但在高风险年龄组（50岁以上）中，只有不到50%的平均风险美国人接受了筛查。随着年龄的增长，结肠和/或息肉的个人和家族病史是最常见的危险因素。APC突变后，腺瘤的形成和发展机制被证明是复杂的。这四个项目的综合方法从几个不同的角度解决了这些问题。生物统计学核心（Core D）为所有犹他大学结肠癌PPG项目、核心、研究者和参与者提供统计专业知识。核心成员合作：1)实验室和临床研究的设计、实施和分析；2)开发和应用新的统计方法和分析算法，以解决与PPG项目相关的问题。核心员工将作为研究团队的合作成员，共同制定设计和分析计划，以解决研究问题。生物统计学核心提供的功能包括开发实验设计、参与研究实施、数据质量监测、统计分析和解释发现，以及合作展示结果。为了实现这些功能，核心主任和生物统计学家与项目调查员合作，并与项目和核心领导人定期联系。生物统计学核心的主要目标是：1)提供所有实验室、动物和临床研究的研究设计和审查，包括可行性评估、功效分析和样本量

Colorectal cancer is the third most commonly diagnosed cancer and the second leading cause of cancer-related deaths in the United States and the developed world. Despite the availability of proven effective preventive screening tools, less than 50% of average risk Americans in the high-risk age group (over 50) have been screened. After age, personal and family history of colon and/or polyps is the most common risk factor. Following APC mutation, the mechanisms of adenoma formation and progression are proving complex. The integrated approach of the 4 projects addresses these issues from several different perspectives. The Biostatistics Core (Core D) provides statistical expertise for all University of Utah Colon Cancer PPG projects, cores, investigators and participants. Core members collaborate in 1) the design, implementation, and analysis of laboratory and clinical research studies, and 2) the development and application of new statistical methods and analysis algorithms to address problems relevant to PPG projects. Core staff will function as collaborative members of research teams to jointly develop design and analysis plans to address research questions. Functions provided by the Biostatistics Core include development of experimental designs, participation in study implementation, data quality monitoring, statistical analysis and interpretation of findings, and collaboration on presentation of results. To achieve these functions, the Core director and biostatisticians collaborate with project investigators, and are in regular contact with the project and core leaders. The primary objectives of the Biostatistics Core are 1) To provide study design and review of all laboratory, animal and clinical studies including feasibility assessment, power analysis and sample size calculation. 2) To collaborate in projects' data analysis, interpretation of results, and the writing of final study reports and manuscripts. 3) To work with the Analytical Core (Core B) and Clinical Core (Core C) in their activities to ensure data quality and timely data capture. 4) To develop and evaluate statistical methods for experimental design and data analysis as required for PPG projects. The Biostatistics Core supports all four Colon Cancer PPG projects at the University of Utah.