Translational Research Capacity Building Initiative to Address Cardiovascular Diseases in Nepal

项目摘要/摘要 尼泊尔应对心血管疾病的翻译研究能力建设倡议 心血管疾病是世界上导致过早死亡的主要原因，占80%以上。 在低收入和中等收入国家发生的所有与心血管疾病有关的死亡中。在尼泊尔，心血管疾病及其危险因素 在过去的几十年里以惊人的速度增长。尽管有经过验证的预防和预防措施 对于心血管疾病的适当管理，实施已知干预措施的挑战严重受限于 在以下方面存在差距：a)对心血管疾病及其风险因素的流行病学了解；b)国家一级的政策和战略 解决这些问题；c)提供教育和治疗的保健系统基础设施；d)社区和 在地方一级提供病人一级的支持；以及e)人力资源，以领导和执行议程 发展起来的。为了弥补这些差距，这个拟议的项目计划在尼泊尔建设国家领导能力 通过创建和培训多部门、多领域的跨国心血管疾病研究(CVD) 纪律团队；与美国和地区机构建立伙伴关系；系统评估国家 需要；以及制定可操作的翻译研究计划。具体目标是：1)创建一个多元化的 部门、多学科协作团队领导翻译研究能力建设倡议 在尼泊尔预防和管理心血管疾病；2)评估国家一级的基础设施和执行证据的能力 尼泊尔的心血管疾病预防和管理干预措施及其风险因素；3)确定并确定优先顺序 尼泊尔心血管疾病的健康问题；4)准备一份全面的可操作的翻译 尼泊尔心血管疾病管理研究计划。我们将巩固与美国大学现有的合作伙伴关系 (华盛顿大学、威斯康星大学、哈佛大学的教职员工)并建造新的 与区域机构(印度公共卫生基金会、中国中山大学)建立伙伴关系，以 支持这些努力。我们将采用混合方法(定性和定量)来评估现有的 政府和非政府部门的能力、需求、机遇和挑战 实施循证干预措施，预防和管理心血管疾病。我们将进行第二次 利用全国调查资料、医院资料和医院资料对心血管疾病流行病学资料进行分析 已发表和未发表的研究，以确定区域、性别、 尼泊尔的种族和收入群体。我们将开始努力通过试点登记来确定心肌梗塞和中风。通过 在项目结束时，我们将在尼泊尔开发一批关键的人力资源，与 国家和国际合作伙伴在心血管疾病方面开展翻译研究。我们会有明确的定义 确定优先顺序的需求和明确定义的实施研究计划，以解决一个或多个主要问题 心血管疾病危险因素和预后。因此，该团队将在#年成立翻译研究英才中心。 心血管疾病》，这也将成为世界各地其他资源受限环境的典范。 世界。

PROJECT SUMMARY/ABSTRACT Translational Research Capacity Building Initiative to address Cardiovascular Diseases in Nepal Cardiovascular diseases (CVDs) are the leading causes of premature death in the world with more than 80% of all CVD-related deaths occurring in low-and middle-income countries. In Nepal, CVD and their risk factors have increased alarmingly over the past decades. Although there are proven measures for prevention and appropriate management of CVD, the challenges of implementing known interventions are severely limited by gaps in: a) epidemiological understanding of CVD and its risk factors; b) national level policies and strategies to address them; c) health systems infrastructure to provide education and treatment; d) community and patient-level support at the local level; and e) human resources to lead and implement agendas when they are developed. To address these gaps, this proposed project plans to build national capacity in Nepal to lead transnational research in cardiovascular disease (CVD) by creating and training a multi-sectorial, multi- disciplinary team; building partnership with the US and regional institutions; systematically assessing national needs; and developing an actionable translational research plan. Specific aims are to: 1) Create a multi- sectorial, multidisciplinary collaborative team to lead the translational research capacity building initiative to prevent and manage CVD in Nepal; 2) Assess national level infrastructure and capacity to implement evidence based CVD prevention and management interventions and its risk factors in Nepal; 3) Identify and prioritize health issues for cardiovascular disease in Nepal; 4) Prepare a comprehensive actionable translational research plan for management of CVD in Nepal. We will consolidate existing partnerships with US Universities (University of Washington, University of Wisconsin, Faculties from Harvard University) and build new partnerships with regional institutions (Public Health Foundation of India, Sun-Yat-Sen University in China) to support these efforts. We will apply mixed methods (qualitative and quantitative) to assess the existing capacity, needs, opportunities and challenges among the governmental and non-governmental sectors to implement evidence-based interventions for prevention and management of CVD. We will conduct secondary data analysis on epidemiology of CVD by using data sources from national surveys, hospital-based data and published and unpublished research to identify the epidemiology of CVD in the context of region, gender, ethnicity, and income groups of Nepal. We will initiate efforts to ascertain MI and stroke via a pilot registry. By the end of the project, we will have developed a critical mass of human resources in Nepal, collaborating with national and international partners to conduct translational research in CVD. We will have defined clearly identified prioritized needs and a well-defined implementation research plan to address one or more major CVD risk factors and outcomes. The team will thus form a ‘Center of Excellence for Translational Research in Cardiovascular Diseases’, which will also serve as a model for other resource-constrained settings around the world.