Research Education Core

研究教育组成部分项目摘要/摘要 在阿尔茨海默病和相关痴呆症(ADRD)中，一个快速发展的领域获得了 对一系列可能的互补疾病机制的全面洞察，有助于了解相关 遗传和环境因素，神经病理异常的连续体，代表 疾病的早期阶段，以及一系列的临床表现。然而，知识上的巨大差距仍然存在。 关于疾病模型、遗传学和病理生理学，当然还有治疗。哥伦比亚大学 (Cu)研究教育部分(REC)将是一个全面的培训方案，以有效和 高效培养下一代ADRD领导人，准备在ADRD研究方面取得突破 既有既定的研究方法，也有新颖的研究方法。CU REC培训计划将提供以下培训 研究人员由两个不同的群体组成：a)通过常规培训进入ADRD研究的人员 路径(例如，神经学家、神经心理学家、基础研究人员和翻译研究人员)有很大的希望 在短期内对该领域做出贡献，以及b)来自非常规途径的研究人员(例如， 生物信息学/数据科学、工程学、公共卫生和联合卫生)，他们展示了独特和 成熟的研究技能，如果重新定位到ADRD，可能会对ADRD产生新的和重要的影响 研究。REC培训计划加强了CU ADRC的主要目标：支持和增强 CU在ADRD正在进行的研究工作，并支持不同的ADRD研究人员团队做出这些 发现。CU REC培训计划提供了一个有前途的初级研究人员的结构化框架， 通过我们庞大的机构研究基础设施确定，可以利用在以下领域建立成功的职业生涯 阿德勒。通过与结构化研究项目捆绑在一起的持续多学科指导，有效地支持 初级研究人员可以独立开发假设，批判性地评估相关文献，并构建一个 对经过适当磨练的研究问题采取复杂的方法。培训将包括个性化的 为每个学员及其目前和未来的职业发展步骤量身定做的发展计划，使 对启动成功的研究事业的基础性理解。这一计划将建立在 CU ADRC和神经内科的长期做法，后者拥有最高的轨道 受训人员成为世界上任何机构的学术神经学家的记录。总而言之，首要目标是 REC培训计划的目的是通过以下方式培养下一代ADRD研究人员：1)确定3-5名 初级调查人员，承诺对反兴奋剂领域作出重大贡献(目标1)；2)绘图 来自ADRD领域以及传统研究途径以外领域的受训人员，特别是那些 来自不同背景(目标2)；以及3)为所有受训人员提供个性化的发展计划， 包括多学科指导，在广泛的内部研究和教育中的经验 CU的计划，以及了解如何获得和实现持续赠款支持的综合计划 迈向下一步职业发展(目标3)。

RESEARCH EDUCATION COMPONENT PROJECT SUMMARY/ABSTRACT In Alzheimer’s Disease and Related Dementias (ADRD), a rapidly developing field has gained comprehensive insights into a host of likely complementary disease mechanisms, shedding light on relevant genetic and environmental factors, a continuum of neuropathological abnormalities, biomarkers that represent the earliest stages of disease, and an array of clinical presentations. Yet, large gaps in knowledge remain regarding disease modeling, genetics and pathophysiology, and of course, treatment. The Columbia University (CU) Research Education Component (REC) will be a comprehensive training program to effectively and efficiently develop the next generation of ADRD leaders poised to make breakthroughs in ADRD research through both established and novel research methods. The CU REC Training Program will provide training for researchers comprising two distinct groups: a) those entering ADRD research through conventional training paths (e.g., neurologists, neuropsychologists, basic and translational researchers) with great promise to contribute to the field in the near term, and b) researchers from non-conventional paths (e.g., bioinformatics/data science, engineering, public health, and allied health) who have demonstrated unique and accomplished research skills, which if reoriented to ADRD, could make novel and important impacts on ADRD research. The REC Training Program enhances primary aims of the CU ADRC: to enable and enhance ongoing research efforts in ADRD at CU, and support a diverse group of ADRD researchers making these discoveries. The CU REC Training Program provides a structured framework that promising junior researchers, identified through our vast institutional research infrastructure, can leverage to establish successful careers in ADRD. With ongoing, multidisciplinary mentorship tied to a structured research project, effectively supported junior researchers can independently develop hypotheses, critically appraise related literature, and frame a sophisticated approach to an appropriately honed research question. Training will include an individualized development plan tailored to each trainee and his or her current and future career steps, enabling a foundational understanding from which to launch a successful research career. This program will build upon the longstanding practices of the CU ADRC and Department of Neurology, the latter having the highest track record of trainees becoming academic neurologists of any institution in the world. In sum, the overarching goal of the REC Training Program is to develop the next generation of ADRD researchers by: 1) identifying 3-5 junior investigators with promise for making significant contributions to the field of ADRD (Aim 1); 2) drawing trainees from ADRD fields as well as fields beyond traditional pathways to ADRD research, especially those from diverse backgrounds (Aim 2); and 3) providing all trainees with an individualized development plan that includes multidisciplinary mentorship, experiences within the expansive internal research and education program at CU, and an integrated plan to understand how to access and achieve sustained grant support towards next career steps (Aim 3).