National Consortium on Alcohol and Neurodevelopment in Adolescence: San Diego

项目总结 在年轻的成年期，饮酒急剧增加，狂欢程度的饮酒在22岁时达到顶峰，几乎 报告说有一半的人酗酒。长期频繁酗酒 持续到25岁左右的神经成熟可能会比类似的酒精对大脑和认知产生更大的影响 在成年后使用。为响应RFA-AA-17-003，本申请提出了一个研究项目站点 青少年酒精与神经发育第二阶段国家联合会(NCANDA-2) 确定青少年在青春期和青春期大量饮酒的预测因素和影响。至 实现这一目标，UCSD的NCANDA-2站点将继续遵循211个圣地亚哥地区的队列(n=831 所有5个站点)参与者(基线访问的年龄为12-21岁)，以获取必要的数据以促进我们的理解 青少年发育和青春期饮酒对成年大脑的影响。NCANDA-2将 使用多模式神经成像、认知测试、行为评估、生物样品采集和多模式 对自然环境的评估。酒精后果的审查将集中在结构性和 在青春期和成年期活跃发育的大脑区域的功能成熟也参与其中。 在心理调节中，对奖励做出反应，似乎很容易受到酒精的神经毒性影响。在……里面 此外，加州大学圣迭戈分校的网站将与杜克大学和俄亥俄州立大学的网站合作，研究这些异常的恢复。 具体来说，我们将检查大量饮酒在多大程度上与神经认知和大脑相关 诚信缺陷缓解了持续4周的禁欲。加州大学圣迭戈分校还将与SRI网站合作 收集fMRI环境中的Stroop任务以评估青少年认知控制系统的变化 增加饮酒量的人与不增加饮酒量的人相比。发育的性别差异、饮酒方式和 病史，酒精使用对大脑的影响，以及性别差异的心理社会因素(例如，抑郁 症状)将在分析中考虑。利用此次续签提供的额外纵向数据，我们将 确定酒精暴露对青少年大脑发育轨迹的影响，以及 确定可能改变青少年和年轻人的先前存在的心理生物脆弱性和复原力 酒精或其他物质使用障碍的风险以及其他心理健康和发育结果。

PROJECT SUMMARY During young adulthood, drinking dramatically increases, with binge-level drinking peaking at age 22 and nearly half of individuals reporting binge-level alcohol use. Frequent binge alcohol use during the protracted neuromaturation spanning into the mid-20s may result in greater brain and cognitive effects than similar alcohol use in later adulthood. In response to RFA-AA-17-003, this application proposes a Research Project Site of the National Consortium on Alcohol and Neurodevelopment in Adolescence second phase (NCANDA-2) to determine the predictors and effects of heavy adolescent alcohol use in adolescence and young adulthood. To achieve this, the UCSD site of NCANDA-2 will continue to follow a cohort of 211 San Diego-area (n=831 across all 5 sites) participants (ages 12-21 at baseline visit) to acquire the necessary data to advance our understanding of adolescent development and the effects of alcohol use during adolescence on the adult brain. NCANDA-2 will use multimodal neuroimaging, cognitive testing, behavioral assessment, biospecimen collection, and multimodal assessments in the natural environment. The examination of alcohol consequences will focus on structural and functional maturation of brain areas that actively develop during adolescence and young adulthood, are involved in psychological regulation, respond to rewards, and appear vulnerable to neurotoxic effects of alcohol. In addition, the UCSD site will collaborate with the Duke and OHSU sites to study recovery of these abnormalities. Specifically, we will examine the degree to which targeted heavy drinking related neurocognitive and brain integrity deficits remit over 4 weeks of monitored abstinence. UCSD will also collaborate with the SRI site to collect the Stroop task in the fMRI environment to evaluate changes in the cognitive control system for youth who increase drinking versus those who do not. Sex differences in development, alcohol use patterns and history, impact of alcohol use on the brain, and sex-differentiating psychosocial factors (e.g., depression symptoms) will be considered in analyses. With the additional longitudinal data provided by this renewal, we will determine the effects of alcohol exposure on the developmental trajectory of the adolescent human brain, and identify preexisting psychobiological vulnerabilities and resiliencies that may alter adolescents’ and young adults’ risk for alcohol or other substance use disorder and other mental health and developmental outcomes.