Project 3 - Development and Field Application of Novel Ultrasensitive Devices for the Measurement of Airborne VOCs

项目概要（项目3） 本论文的研究工作旨在推进空气中挥发性有机化合物（VOC）的检测和定量 技术，并强有力地表征室内/室外对比度和家庭内的决定因素， 针对超级基金相关的挥发性有机化合物。这项研究将继续增长和扩大两个VOC实时原位 路易斯维尔大学超级基金研究中心开发的测量平台， 2017.一个平台包括小型、低成本的传感器，可以单独部署或部署在网络中。新型气体 正在开发传感器和传感器阵列以测量目标超级基金相关的VOC， 三氯乙烯（TCE）、苯、甲苯、乙苯和二甲苯（BTEX）。该装置采用新颖的表面 解决选择性和灵敏度的共同挑战，并使用 微机电系统（MEMS）技术。另一个平台满足了灵活 设计，现场部署的仪器，可以测量高灵敏度的化合物， 用复杂的VOC混合物询问微环境。多通道有机物原位环境 在中心资助的第一个周期中开发的用于移动的监测的MOIRA分析仪将被 针对室内/室外VOC监测研究进行了扩展和优化。MOIRA是一种气相色谱-质谱联用仪， 具有高时间分辨率的光谱分析（GC-MS）仪器（例如，10分钟）。它的能力将得到扩展 以测量比当前设计所能实现的更高和更低挥发性的化合物。这些 创新的、高时间分辨率的现场测量将与传统的时间积分VOC相结合 被动采样，以测量目标超级基金相关的挥发性有机化合物在一些参与者的家中，在盟军的临床 study.这些数据将用于建立时空模型，以估计所有人家中的环境VOC。 临床研究参与者，并获得新的见解挥发性有机化合物水平及其决定因素在家里 微环境除了暴露评估外，这两个测量平台还响应 正在进行的超级基金计划的进步;这些创新的发展将扩大未来的能力， 监测VOC室内蒸汽侵入，监测现场修复期间的室外VOC水平，并监测两者 在修复后监测期间进行室内和室外监测。

PROJECT SUMMARY (Project 3) This proposed work is to advance airborne volatile organic compound (VOC) detection and quantification technologies, and to robustly characterize indoor/outdoor contrast and in-home determinants for exposures to target Superfund-relevant VOCs. This research will continue to grow and expand two VOC real-time in situ measurement platforms developed by the University of Louisville Superfund Research Center established in 2017. One platform comprises small, low-cost sensors that can be deployed alone or in networks. Novel gas sensors and sensor arrays are being developed to measure target Superfund-relevant VOCs including acrolein, trichloroethene (TCE), benzene, toluene, ethylbenzene, and xylene (BTEX). The devices use novel surface chemistries to address the common challenges of selectivity and sensitivity and are fabricated using microelectromechanical systems (MEMS) technology. Another platform addresses the need for flexibly designed, field-deployable instruments that can measure with high sensitivity a large range of compounds to interrogate microenvironments with complex VOC mixtures. The Multichannel Organics In-situ enviRonmental Analyzer (MOIRA) instrument, developed in the first cycle of Center funding for mobile monitoring, will be expanded and optimized for indoor/outdoor VOC monitoring studies. MOIRA is a gas chromatography–mass spectrometry (GC-MS) instrument with high time resolution (e.g., ten minutes). Its capabilities will be expanded to measure both higher and lower volatility compounds than can be achieved with the current design. These innovative, high time resolution in situ measurements will be coupled with conventional time-integrated VOC passive sampling to measure target Superfund-relevant VOCs at homes of some participants in the allied clinical study. These data will be used to build spatiotemporal models to estimate ambient VOCs at the homes of all clinical study participants, and to gain new insights into VOC levels and their determinants in the home microenvironment. In addition to exposure assessment, the two measurement platforms are responsive to ongoing Superfund program advancements; these innovative developments will expand future capacities to monitor VOC indoor vapor intrusion, monitor outdoor VOC levels during site remediation, and monitor both indoors and outdoors during post-remediation surveillance.