Transport and bioavailability of U and co-occurring metals in nanoparticulate matter on tribal lands affected by mining legacy

项目2 -环境项目2 - ESE颗粒（ESE PM）-项目总结 纳瓦霍族和拉古纳普韦布洛部落土地上的废弃铀矿 是环境污染的主要来源，由于 含有铀（U）、钒（V）、铜（Cu）、砷（As）的有毒金属混合物的活化。的 有毒金属混合物以纳米颗粒形式进入空气， 吸入和摄入接触，从来没有以严格的方式进行过调查。拟议 研究将调查纳米颗粒中有毒金属混合物的潜在暴露危害， 来自纳瓦霍民族的AUM地点的受污染农作物的吸入和摄入， 拉古纳普韦布洛部落在亚利桑那州和新墨西哥州的土地。该项目将针对两个具体目标： 1)了解各种金属混合物的物理化学特性和分布， 环境样本，包括矿山废物、土壤（农业和背景）和空气中的微粒 围绕AUM和模拟其运输和沉积风到邻近社区; 2）评估 废弃矿址附近农业土壤上的植物对金属的吸收，以了解是否通过空气传播 含有金属的微粒存在潜在的暴露风险。（3）了解 通过试验，通过农作物的根和叶系统将颗粒同化到农作物中， 建立了一个含金属颗粒物从AUM站点再悬浮和传输到 估计附近脆弱社区的暴露风险。对于流程模型，我们将a）确定 来自AUM站点的含金属PM的粒度分布和矿物学特征， 生活在不同气象条件下的区域空气流通区内的脆弱人群的暴露潜力 B）对该区域进行源-受体建模，整合来自三个方面的信息 性能网站和推导纳瓦霍社区成员的长期估计。拟议研究 将利用最先进的监测、化学、成像和大气建模技术， 关于浓度、形态、化合价、溶解度等的综合数据集，超细颗粒粉末冶金 纳米颗粒尺度，这是必不可少的，以评估潜在的毒性和吸入暴露风险的PM。的 结果将减少有关金属含量、暴露浓度和AUM来源的不确定性， 风险降低策略中相关的PM暴露。

PROJECT 2 - ENVIRONMENTAL PROJECT 2 – ESE Particulate (ESE PM) - PROJECT SUMMARY Abandoned uranium mines (AUM) situated on the tribal lands of the Navajo Nation and Laguna pueblo represent a major source of environmental contamination that threatens public health as a result of mobilization of toxic metals mixtures bearing uranium (U), vanadium (V), copper (Cu), arsenic (As). The transport of toxic metals mixtures into the air in nanoparticulate form, and the subsequent potential for inhalational and ingestion exposures, has never been investigated in a rigorous manner. The proposed research will investigate the potential exposure hazards to toxic metals mixtures in nanoparticulates resulting from inhalation and ingestion via contaminated agricultural crops from AUM sites located on Navajo Nation and Laguna Pueblo tribal lands in Arizona and New Mexico. The project will address the two specific aims: 1) Understanding the physicochemical characteristics and distribution of metals mixtures in a range of environmental samples, including mine wastes, soils (agricultural and background) and airborne particulates around AUM and modelling their transport and deposition by wind into neighboring communities; 2) Assessing the uptake of metals into plants on agricultural soils adjacent to abandoned mine sites to understand if airborne metals-bearing particulates present a potential exposure risk. and 3) understanding the mechanisms of particulate assimilation into agricultural crops through their root and folial system through experimental stDeveloping a process model for the resuspension and transport of metal-bearing PM from AUM sites to estimate exposure risks for nearby vulnerable communities. For the process model, we will a) ascertain the particle size distributions and mineralogic characteristics of metal-bearing PM originating from AUM sites and the exposure potential to vulnerable populations living in the regional airshed under varied meteorological conditions; and b) conduct source-receptor modeling for the region, integrating information from three performance sites and deriving long-term estimates for Navajo community members. The proposed research will utilize state-of-the-art monitoring, chemical, imaging and atmospheric modeling techniques to provide a comprehensive dataset on the concentrations, speciation, valence, solubility, etc., of ultrafine-grained PM nanoparticle scale that are essential to evaluate the potential toxicity and inhalation exposure risk for PM. The results will reduce uncertainty regarding the metal content, exposure concentrations, and sources of AUM- related PM exposures in risk reduction strategies.