人工、人性化干细胞生态位-猫眼课题宝

人工、人性化干细胞生态位

批准号：

10192715

负责人：

Biju Parekkadan

金额：

$54.22万

依托单位：

RUTGERS, THE STATE UNIV OF N.J.

依托单位国家：

美国

项目类别：

财政年份：

2011

资助国家：

美国

项目状态：

已结题

起止时间：

2011-08-01 至 2023-05-31

来源：

https://reporter.nih.gov/project-details/10192715

关键词：

3-Dimensional Anatomy Area Biopsy Biopsy Specimen Bioreactors Blood Vessels Bone Marrow Bone Marrow Cells Bone Marrow Diseases Bone Marrow Stem Cell Bone marrow biopsy Cell Adhesion Molecules Cell Line Cells Clinical Clinical Trials Companions Cultured Cells Custom Diagnostic Discontinuous Capillary Disease Disease Progression Dysmyelopoietic Syndromes Endothelium Engineering Engraftment Environment Exposure to Extracellular Matrix Freezing Future Generations Genetic Engineering Goals Grant Growth Growth Factor Hematology Hematopoietic stem cells Human Implant Incidence Institution Intuition Lesion Letters Liquid substance Longitudinal Studies Malignant Neoplasms Marrow Measures Mechanics Methods Microfluidics Modeling Mus Oncology Outcome Patient-Focused Outcomes Patients Perfusion Pharmaceutical Preparations Property Protocols documentation Recreation Research Risk Sampling Standardization Stromal Cells Structure System Technology Testing Tissue Engineering Tissue Sample Tissues Variant Vision Xenograft Model Xenograft procedure bone bone engineering cancer stem cell cell bank cellular engineering chemotherapy cytokine cytopenia design environmental enrichment for laboratory animals fluid flow genetically modified cells hematopoietic stem cell expansion hematopoietic stem cell self-renewal hydrogel scaffold individual patient innovation leukemia leukemic transformation miniaturize next generation novel strategies osteoprogenitor cell overexpression progenitor prognostic prognostic value prospective risk stratification scaffold stem cell niche stem cells translational research program tumor microenvironment

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Abstract This project will develop and verify a microtissue engineered bioreactor platform to expand bone marrow cancer stem cells and create xenograft models using frozen MDS patient marrow cells. The project specific aims are: (1) Specific Aim 1: Microfluidic bioreactor for human HSC expansion from a low volume marrow sample; (2) Specific Aim 2: Genetically engineered scaffolds to recreate a MDS microenvironment ex vivo; and (3) Specific Aim 3: Ex vivo differentiation testing of MDS stem cells to predict leukemic transformation. The deliverable of the project will be a qualified bioreactor culture system and protocol to expand rare cells, such as pre-leukemic stem cells, from a small volume bone marrow biopsy tissue sample for use in prospective clinical trials.

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