Translational Regulation of T Regulatory Cells

项目摘要 这项工作的目标是对T法规的翻译调控有一个基本的理解 细胞(Treg)的发育，其中知之甚少，它可以更有效地通知发育 人类癌症和自身免疫性疾病中调节Tregs的治疗方法。我们的研究 为Treg中选择性mRNA翻译的分子调控提供了重要的见解 我们最终寻求利用的发展，以产生更有效的基于免疫的 治疗。这部作品旨在理解并瞄准特雷格·命运的特权翻译 确定mRNAs。本研究的目的是在翻译水平上确定翻译的机制 控制哪些关键的Treg mRNAs促进Treg发育和免疫抑制功能。

Project Summary The goal of this work is to develop a fundamental understanding of the translational regulation of T regulatory cell (Treg) development, of which very little is known, which can inform the development of more effective therapeutic approaches to the regulation of Tregs in human cancer and autoimmune disease. Our research has provided important insights into the molecular regulation of selective mRNA translation in Treg development which we ultimately seek to capitalize on in generation of more effective immune-based therapies. This work is directed to understanding and then targeting the privileged translation of Treg fate determining mRNAs. The objective of our research is to determine the mechanism at the level of translational control which key Treg mRNAs promote Treg development and immune suppression functions.