Theory and Modeling of the Orofacial Active Sensation

项目4。摘要 口面主动感觉的理论和建模（Golomb为主导; Freund;克莱菲尔德） 本研究计画探讨主动感觉的感觉运动脑干回路的动态。 我们最初的重点是在触须系统，鉴于相对过剩的信息，这方面的口面 行为在我们的模型中的具体元素包括触须，触须运动植物，感觉和 运动神经节和核。我们将使用理论和计算技术来描述 几个“组件”的活动，以及感知的普遍性，积极反馈如何改变性质 作为主动感知的结果的感觉输入。 首先，我们将分析触须和运动植物的相互作用，特别是接触如何影响 以及触须上的力和扭矩。然后，我们量化了机械转换 触须运动过程中触须囊对三叉神经节神经元放电的信号 触摸物体。在运动脑干水平，我们探索放电的产生和同步 运动神经元和前运动神经元的模式，以及它们被前Bötzinger复合体重置。最后我们将 构建更大的脑干回路模型，并探索感觉信号如何控制运动的一般问题 行为期间的活动。 我们的模型将受到来自研究项目1的连接数据和关于以下内容的生理数据的约束： 来自研究项目2和3的口面探索电路的激活和操作，及其 预测将在研究项目2和3中进行测试。

Project 4. Abstract Theory and modeling of the orofacial active sensation (Golomb as lead; Freund; Kleinfeld) This Research Project addresses the dynamics of the sensorimotor brainstem circuits for active sensing. Our initial focus is on the vibrissae system, given the relative plethora of information on this aspect of orofacial behavior. The specific elements in our model include the vibrissae, the vibrissa motor plant, and sensory and motor neuronal ganglia and nuclei. We will use theoretical and computational techniques to describe the activity of several "Components" and, of great generality to perception, how active feedback alters the nature of the sensory input as a consequence ofs active sensing. First we will analyze the interaction of the vibrissae and the motor plant, specifically how contact effects the motor plant and the forces and torques on the vibrissae. We then quantify the transformation of mechanical signals in whisker follicle to neuronal spiking of trigeminal ganglion neurons during vibrissa movement and touch with object. At the motor brainstem level, we explore the generation and synchronization of firing patterns of motoneurons and pre-motoneurons, and their reset by the pre-Bötzinger complex. Finally, we will construct models of larger brainstem loops and explore general issues of how sensory signals control motor activity during behavior. Our models will be constrained by connectivity data from Research Project 1 and physiological data about the activation and operation of orofacial exploratory circuitry from Research Project 2 and 3, and their predictions will be tested in Research Project 2 and 3.