Post-Vent, the Sequelae: Personalized Prognostic Modeling for Consequences of Neonatal Intermittent Hypoxemia in Preterm Infants at Pre-School Age

项目总结/摘要 这是早产相关通气控制（Pre-Vent）合作者的应用： 呼吸结局NHLBI合作计划。这项建议的核心是一项前瞻性研究， “排气后，后遗症：新生儿间歇性心脏病后果的个性化预后建模” 学龄前早产儿的低氧血症”。该多中心提案创新性地结合了详细的 通过对间歇性低氧血症（IH）事件纵向记录的高级分析进行临床表型分析， 开发个性化的长期预后模型，通过允许 及时识别高危婴儿和特定的病理性IH模式，以便将来进行针对性干预试验。 极端早产和各种产后因素会对结果产生负面影响。在相当大比例 极早产儿的后遗症持续到婴儿期以后，哮喘和睡眠的发生率相对较高 儿童期呼吸障碍（SDB）和令人担忧的神经发育障碍（NDI）患病率。 这项多中心的建议将系统地和创新地研究新生儿期IH之间的相互作用， 通过详细的临床表型分析和先进的分析，我们可以对重症监护和这些后遗症进行评估。的 拟议的调查将提供个性化的预后和识别婴儿的风险， 这一结果可能会改变临床护理，并发现预防或治疗策略的目标。 这项建议的主要目标是建立哮喘，SDB和NDI在学龄前儿童的预后模型， 基于新生儿生理波形和临床特征的极早产儿 加护病房为了实现这一目标，这一时间敏感的建议利用人口，研究结构， 和专业知识，以及为NHLBI资助的Pre-Vent合作开发的分析资源。

Project Summary / Abstract This is the application from collaborators of the Prematurity-Related Ventilatory Control (Pre-Vent): Role in Respiratory Outcomes NHLBI Collaborative Program. Central to this proposal is a prospective study entitled “Post-Vent, the Sequelae: Personalized Prognostic Modeling for Consequences of Neonatal Intermittent Hypoxemia in Preterm Infants at Pre-school Age”. This multicenter proposal innovatively combines detailed clinical phenotyping with advanced analytics of longitudinal recordings of intermittent hypoxemia (IH) events to develop personalized prognostic models of long-term outcomes that could transform clinical care by allowing for timely identification of at-risk infants and specific pathologic IH patterns for future trials of targeted intervention. Extremely premature birth and various postnatal factors can negatively affect outcome. In a significant proportion of extremely premature infants the sequelae persist beyond infancy with relatively high rates of asthma and sleep disordered breathing (SDB) in childhood and worrisome prevalence of neurodevelopmental impairment (NDI). This multicenter proposal will systematically and innovatively examine the interaction between IH during neonatal intensive care and these sequelae by means of detailed clinical phenotyping and advanced analytics. The proposed investigation will provide personalized prognosis and identification of infants at risk of poor long-term outcome that could transform clinical care and uncover targets for preventive or therapeutic strategies. The main goal of this proposal is to build prognostic models of asthma, SDB, and NDI at pre-school age in former extremely premature infants based on physiologic waveforms and clinical characteristics in the neonatal intensive care unit. To achieve this goal this time-sensitive proposal leverages the population, research structure and expertise, and analytic resources developed for the NHLBI-funded Pre-Vent collaboration.